wMel replacement of dengue-competent mosquitoes is robust to near-term change.

wMel replacement of dengue-competent mosquitoes is robust to near-term change.
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DOI:
10.1038/s41558-023-01746-w
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发表时间:
2023
影响因子:
30.7
通讯作者:
Marshall, John M.
Marshall, John M.
中科院分区:
地球科学1区
文献类型:
--
作者:
Vasquez, Valeri N.;Kueppers, Lara M.;Rasic, Gordana;Marshall, John M.

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气温上升正在影响蚊媒疾病的范围和流行。一种很有前途的生物控制技术用携带病毒阻挡沃尔巴克氏菌的蚊子取代了野生蚊子。由于最广泛使用的菌株wMel受到热应激的不利影响,我们研究了全球变暖可能如何影响基于wMel的替代品。我们利用耦合模式比较项目第五阶段气候预测和历史温度记录,在两个地点成功地模拟了干预措施,将wMel热敏感性的经验数据整合到埃及伊蚊种群动态模型中,以评估一年以上的渗透性和持久性。我们发现,在澳大利亚的凯恩斯,气候预报需要对超过两周的热浪进行操作调整。在越南芽庄,根据对共生体温度极限的最严格假设,预计三周或更长时间的热浪将消除wMel。我们的结论是,这项技术对近期(本世纪30年代)的气候变化总体上是稳健的。全球变暖加速可能会在本世纪50年代及以后挑战这一点。用于缓解蚊媒病毒的生物防治技术(WMel)受到热应激的不利影响。作者综合了蚊子种群动态和wMel热敏感性的经验数据,表明该技术对短期气候变化总体上是稳健的。
Rising temperatures are impacting the range and prevalence of mosquito-borne diseases. A promising biocontrol technology replaces wild mosquitoes with those carrying the virus-blocking Wolbachia bacterium. Because the most widely used strain, wMel, is adversely affected by heat stress, we examined how global warming may influence wMel-based replacement. We simulated interventions in two locations with successful field trials using Coupled Model Intercomparison Project Phase 5 climate projections and historical temperature records, integrating empirical data on wMel’s thermal sensitivity into a model of Aedes aegypti population dynamics to evaluate introgression and persistence over one year. We show that in Cairns, Australia, climatic futures necessitate operational adaptations for heatwaves exceeding two weeks. In Nha Trang, Vietnam, projected heatwaves of three weeks and longer eliminate wMel under the most stringent assumptions of that symbiont’s thermal limits. We conclude that this technology is generally robust to near-term (2030s) climate change. Accelerated warming may challenge this in the 2050s and beyond. The biocontrol technology (wMel) used to mitigate mosquito-borne viruses is adversely affected by heat stress. The authors integrate empirical data on mosquito population dynamics and wMel thermal sensitivity to show that the technology is generally robust to near-term climate change.
DOI: 10.1186/1475-2875-6-98
发表时间: 2007-07-30
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