Personal exposure to air pollution and respiratory health of COPD patients in London.
Personal exposure to air pollution and respiratory health of COPD patients in London.
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DOI：
10.1183/13993003.03432-2020
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Barratt B
中科院分区：
文献类型：
--
作者：
Evangelopoulos D;Chatzidiakou L;Walton H;Katsouyanni K;Kelly FJ;Quint JK;Jones RL;Barratt B
以前的研究已经调查了空气污染对慢性阻塞性肺疾病（COPD）患者的影响，使用固定站点测量或有限数量的个人测量，通常是一种污染物和短时间内。这些限制可能会带来偏见，并扭曲流行病学的关联，因为它们没有考虑到污染的所有潜在来源或时间变异性。我们使用了在精细时空尺度上测量的个人暴露于各种污染物的详细信息，以获得更可靠的影响估计。对一组115名患者进行了平均连续128天的随访，这些患者携带专门为此项目设计的个人监测仪，以1分钟的时间分辨率测量温度、二氧化氮（NO2）、臭氧（O3）、一氧化氮（NO）、一氧化碳（CO）和空气动力学直径<2.5和<10 μm的颗粒物。 每例患者记录每日呼吸道症状信息并测量呼气峰流量（PEF）。一位肺病学家结合相关数据定义了一个表示“急性加重”的二元变量。使用混合效应模型评估了安全性-反应相关性。我们发现气体污染物与患者健康状况的恶化有关。我们观察到NO2、NO和CO四分位数范围增加时，加重几率分别增加16.4%（95% CI 8.6-24.6%）、9.4%（95% CI 5.4-13.6%）和7.6%（95% CI 3.0-12.4%）。对于咳嗽和痰，获得了类似的结果。发现O3与PEF和呼吸困难有不良关联。未观察到颗粒物与任何结局之间的相关性。我们的研究结果表明，当考虑到总的个人暴露于空气污染物，主要是气体污染物影响COPD患者的健康。COPD患者的呼吸系统健康与其个人暴露于使用便携式传感器测量的6个月以上的气体污染物之间存在显著的不良关联。 未发现与颗粒污染物有显著相关性。https://bit.ly/3aqMT6O
Previous studies have investigated the effects of air pollution on chronic obstructive pulmonary disease (COPD) patients using either fixed-site measurements or a limited number of personal measurements, usually for one pollutant and a short time period. These limitations may introduce bias and distort the epidemiological associations as they do not account for all the potential sources or the temporal variability of pollution. We used detailed information on individuals’ exposure to various pollutants measured at fine spatiotemporal scale to obtain more reliable effect estimates. A panel of 115 patients was followed up for an average continuous period of 128 days carrying a personal monitor specifically designed for this project that measured temperature, nitrogen dioxide (NO2), ozone (O3), nitric oxide (NO), carbon monoxide (CO), and particulate matter with aerodynamic diameter <2.5 and <10 μm at 1-min time resolution. Each patient recorded daily information on respiratory symptoms and measured peak expiratory flow (PEF). A pulmonologist combined related data to define a binary variable denoting an “exacerbation”. The exposure–response associations were assessed with mixed effects models. We found that gaseous pollutants were associated with a deterioration in patients’ health. We observed an increase of 16.4% (95% CI 8.6–24.6%), 9.4% (95% CI 5.4–13.6%) and 7.6% (95% CI 3.0–12.4%) in the odds of exacerbation for an interquartile range increase in NO2, NO and CO, respectively. Similar results were obtained for cough and sputum. O3 was found to have adverse associations with PEF and breathlessness. No association was observed between particulate matter and any outcome. Our findings suggest that, when considering total personal exposure to air pollutants, mainly the gaseous pollutants affect COPD patients’ health. Significant adverse associations were found between the respiratory health of COPD patients and their personal exposure to gaseous pollutants measured using portable sensors over 6 months. No significant associations were found for particulate pollutants. https://bit.ly/3aqMT6O
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影响因子：
5
作者：
Mead, M. I.;Popoola, O. A. M.;Jones, R. L.
通讯作者：
Jones, R. L.
影响因子：
5
作者：
Chan, AT;Chung, MW
通讯作者：
Chung, MW
影响因子：
4.9
作者：
de Hartog, J. J.;Ayres, J. G.;Hoek, G.
通讯作者：
Hoek, G.
哮喘或慢性阻塞性肺部疾病的个体中的空气污染和呼吸道症状：欧洲多中心小组研究。
DOI：
10.1186/1476-069x-11-75
发表时间：
2012-10-05
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Karakatsani A;Analitis A;Perifanou D;Ayres JG;Harrison RM;Kotronarou A;Kavouras IG;Pekkanen J;Hämeri K;Kos GP;de Hartog JJ;Hoek G;Katsouyanni K
通讯作者：
Katsouyanni K
DOI：
10.3390/ijerph120910635
发表时间：
2015-08-28
影响因子：
--
作者：
Cortez-Lugo M;Ramírez-Aguilar M;Pérez-Padilla R;Sansores-Martínez R;Ramírez-Venegas A;Barraza-Villarreal A
通讯作者：
Barraza-Villarreal A