Characterization of respiratory drug delivery with enhanced condensational growth using an individual path model of the entire tracheobronchial airways.
Characterization of respiratory drug delivery with enhanced condensational growth using an individual path model of the entire tracheobronchial airways.
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DOI：
10.1007/s10439-010-0223-z
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发表时间：
2011-03
影响因子：
3.8
通讯作者：
Hindle, Michael
中科院分区：
文献类型：
--
作者：
Tian, Geng;Longest, Philip Worth;Su, Guoguang;Hindle, Michael
关键词：
本研究的目的是在从口腔延伸到气管支气管（TB）区域末端的气道模型中，使用增强凝聚生长（ECG）方法评价吸入药物气雾剂的递送。几何形状包括椭圆形口-喉（MT）模型、延伸至分叉B3的上TB气道以及随后进入肺右下叶的个体路径模型。在控制（25 °C，亚饱和空气）或ECG（39或42 °C，饱和空气）条件下，将直径为560和900 nm的亚微米单分散气溶胶输送到口腔入口。流场和液滴特性进行了模拟，使用计算流体动力学模型，以前被证明可以准确地预测气溶胶尺寸的增长和沉积。结果表明，在MT和上TB模型中，对照和ECG递送病例均产生非常少的沉积（约1%）。在心电图输送条件下，观察到气溶胶液滴尺寸大幅增加，导致B5出口的质量中位空气动力学直径为2.4-3.3 μm。与对照组相比，气溶胶尺寸的增加使TB气道内的气溶胶沉积增加了一个数量级，ECG条件下的TB沉积效率约为32-46%。下游肺沉积的估计表明在ECG输送期间气雾剂几乎完全肺滞留。此外，通过控制入口温度条件和初始气溶胶尺寸来瞄准TB沉积区域也是可能的。
The objective of this study was to evaluate the delivery of inhaled pharmaceutical aerosols using an enhanced condensational growth (ECG) approach in an airway model extending from the oral cavity to the end of the tracheobronchial (TB) region. The geometry consisted of an elliptical mouth-throat (MT) model, the upper TB airways extending to bifurcation B3, and a subsequent individual path model entering the right lower lobe of the lung. Submicrometer monodisperse aerosols with diameters of 560 and 900 nm were delivered to the mouth inlet under control (25 °C with subsaturated air) or ECG (39 or 42 °C with saturated air) conditions. Flow fields and droplet characteristics were simulated using a computational fluid dynamics model that was previously demonstrated to accurately predict aerosol size growth and deposition. Results indicated that both the control and ECG delivery cases produced very little deposition in the MT and upper TB model (approximately 1%). Under ECG delivery conditions, large size increases of the aerosol droplets were observed resulting in mass median aerodynamic diameters of 2.4–3.3 μm exiting B5. This increase in aerosol size produced an order of magnitude increase in aerosol deposition within the TB airways compared with the controls, with TB deposition efficiencies of approximately 32–46% for ECG conditions. Estimates of downstream pulmonary deposition indicted near full lung retention of the aerosol during ECG delivery. Furthermore, targeting the region of TB deposition by controlling the inlet temperature conditions and initial aerosol size also appeared possible.
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影响因子：
16.1
作者：
Lai, Samuel K.;Wang, Ying-Ying;Hanes, Justin
通讯作者：
Hanes, Justin
影响因子：
3.3
作者：
HAMMERSLEY, JR;OLSON, DE
通讯作者：
OLSON, DE
DOI：
10.1080/02786821003749525
发表时间：
2010-06-01
期刊：
Aerosol science and technology : the journal of the American Association for Aerosol Research
影响因子：
--
作者：
Longest PW;McLeskey JT Jr;Hindle M
通讯作者：
Hindle M
影响因子：
5.2
作者：
Cheng, YS
通讯作者：
Cheng, YS
DOI：
10.1089/jam.2006.19.473
发表时间：
2006-12-01
期刊：
JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG
影响因子：
--
作者：
Borgstrom, Lars;Olsson, Bo;Thorsson, Lars
通讯作者：
Thorsson, Lars