Placental Impact of Dietary Supplements: More Than Micronutrients.
Placental Impact of Dietary Supplements: More Than Micronutrients.
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膳食补充剂对胎盘的影响：不仅仅是微量营养素。
DOI：
10.1016/j.clinthera.2020.11.017
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发表时间：
2021-03
影响因子：
3.2
通讯作者：
O'Tierney-Ginn P
中科院分区：
文献类型：
--
作者：
Rasool A;Alvarado-Flores F;O'Tierney-Ginn P
母体营养是胎儿生长发育的关键调节因素。然而，在美国，许多产妇的饮食。S.不符合营养建议。因此，膳食补充剂是必要的，以满足营养目标。许多补充剂对胎盘发育和功能的影响知之甚少。在这篇综述中，我们将讨论母体膳食补充剂对健康和复杂妊娠中胎盘发育和功能的治疗潜力。这是对1970年2月至2020年7月期间发表的原始研究文章的叙述性综述，涉及妊娠期间食用的膳食补充剂，并报告胎盘结局（包括营养素吸收，代谢和递送，生长和效率）。胎盘变化对胎儿结局的影响也进行了审查。包括人类和动物研究。我们发现了几种补充剂对母体和胎儿结局的潜在治疗益处的证据，通过它们对胎盘的影响。我们的评论支持益生菌作为胎盘治疗药物的作用，其作用包括改善炎症和脂质代谢，这可能会预防早产和胎盘效率低下。在怀孕期间补充omega-3脂肪酸（如鱼油中所含）可以缓解母体肥胖的负面影响，但对健康的瘦女性胎盘影响不大。补充胆碱对产妇健康和胎儿生长的有益影响主要是由于其对胎盘的影响。发现补充L-精氨酸对胎盘具有强有力的促血管形成作用，这可能是其促进胎儿生长特性的基础。胎盘对膳食补充剂非常敏感。孕妇在继续服用或开始服用膳食补充剂之前，应咨询其医疗保健提供者。由于对许多补充剂对胎盘和长期后代健康的影响知之甚少，因此在提出强有力的临床建议之前需要进行更多的研究。
Maternal nutrition is a key modifier of fetal growth and development. However, many maternal diets in the U. S. don’t meet nutritional recommendations. Dietary supplementation is therefore necessary to meet nutritional goals. The effects of many supplements on placental development and function are poorly understood. In this review we will address the therapeutic potential of maternal dietary supplementation on placental development and function in both healthy and complicated pregnancies. This is a narrative review of original research articles published between Feb 1970 – July 2020, pertaining to dietary supplements consumed during pregnancy, and reporting placental outcomes (including nutrient uptake, metabolism and delivery, growth and efficiency). Impacts of placental changes on fetal outcomes were also reviewed. Both human and animal studies were included. We found evidence for potential therapeutic benefit of several supplements on maternal and fetal outcomes, via their placental impacts. Our review supports a role for probiotics as a placental therapeutic, with effects including improved inflammation and lipid metabolism, which may prevent preterm birth and poor placental efficiency. Supplementation with omega-3 fatty acids (as found in fish oil) during pregnancy tempers the negative effects of maternal obesity, but may have little placental impact on healthy lean women. The beneficial effects of choline supplementation on maternal health and fetal growth are largely due to its placental impacts. L-arginine supplementation was found to have a potent pro-vascularization effect on the placenta which may underlie its fetal growth-promoting properties. The placenta is exquisitely sensitive to dietary supplements. Pregnant women should consult their healthcare provider before continuing with or initiating a dietary supplement. As little is known about impacts of many supplements in placental and long term offspring health, more research is required before robust clinical recommendations can be made.
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DOI：
10.1016/j.bbalip.2010.08.002
发表时间：
2010-12
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Bannenberg G;Serhan CN
通讯作者：
Serhan CN
影响因子：
3.8
作者：
Alvarado, Fernanda L.;Calabuig-Navarro, Virtu;O'Tierney-Ginn, Perrie
通讯作者：
O'Tierney-Ginn, Perrie
影响因子：
3.8
作者：
Cheng, Z.;Elmes, M.;Wathes, D. C.
通讯作者：
Wathes, D. C.
影响因子：
5.9
作者：
Chen Q;Dai W;Sun Y;Zhao F;Liu J;Liu H
通讯作者：
Liu H
影响因子：
17.1
作者：
Aagaard K;Ma J;Antony KM;Ganu R;Petrosino J;Versalovic J
通讯作者：
Versalovic J