Variation in the heritability of body mass index based on diverse twin studies: a systematic review.
Variation in the heritability of body mass index based on diverse twin studies: a systematic review.
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DOI：
10.1111/obr.12065
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发表时间：
2013-11
期刊：
影响因子：
--
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Min J;Chiu DT;Wang Y
在过去的三十年里，对双胞胎的研究表明，肥胖的遗传性存在差异。本研究根据人口特征（如性别、年龄、观察时间段和平均BMI）以及国家人均国内生产总值（GDP）和GDP增长率等广泛的社会环境因素，考察了体质指数（BMI）遗传力（BMI- h）的差异。在PubMed中检索1990年1月至2011年2月期间以英文发表的报告BMI-H的双胞胎研究，排除疾病、特殊职业或国家/种族群体的综合遗传力估计。32项研究来自芬兰（7项）、英国（6项）、美国（3项）、丹麦（3项）、中国（3项）、荷兰（2项）、韩国（2项）、瑞典（2项）和其他国家（4项）。采用随机效应的Meta回归模型分析BMI-H的变化。BMI- h的异质性主要归因于年龄（<20岁、20 - 55岁和≥56岁）、观察时间（即数据收集年份）、平均BMI和GDP（≤20,000美元、20,001-26,000美元和> 26,000美元）的差异。在过去几年的研究中，青少年（<20岁）以及平均bmi较高或人均GDP较高（≥26,000美元）的人群中BMI-H高于同龄人。通过GDP的分层分析，发现高GDP增长率（>中位数）对BMI-H的持续降低效应。在国内生产总值处于中等水平的国家，特别是那些经济快速增长的国家，BMI-H较低。BMI- h对年龄、观察时间、平均BMI、GDP、经济快速增长等敏感。
Over the past three decades, twin studies have shown variation in the heritability of obesity. This study examined the difference of body mass index (BMI) heritability (BMI-H) by population characteristics, such as sex, age, time period of observation, and average BMI, as well as by broad social-environmental factors as indicated by country-level gross domestic product (GDP) per capita and GDP growth rate. Twin studies that reported BMI-H and were published in English from Jan 1990 to Feb 2011 after excluding those with disease, special occupations or combined heritability estimates for country/ethnic groups were searched in PubMed. 32 studies were identified from Finland (7), the UK (6), the US (3), Denmark (3), China (3), Netherlands (2), South Korea (2), Sweden (2) and four from other countries. Meta regression models with random effect were used to access variation in BMI-H. Heterogeneity of BMI-H is significantly attributable to variations in age (<20yr, 20–55yr & ≥56yr), time period of observation (i.e., year of data collection), average BMI, and GDP (≤$20,000, $20,001–26,000 & >$26,000). BMI-H was higher in adolescents (<20yr), in studies done in past years, and in populations with higher average BMIs or higher GDP per capita (≥$26,000) than their counterparts. Consistent lowering effects of high GDP growth rate (>median) on BMI-H were shown through stratified analyses by GDP. BMI-H was lower in countries of mid-level GDP, particularly those experiencing rapid economic growth. BMI-H is sensitive to age, time period of observation, average BMI, GDP, and rapid economic growth.
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青春期对体重指数的遗传和环境影响：芬兰双胞胎的一项前瞻性研究。
影响因子：
4.9
作者：
Lajunen, H-R;Kaprio, J.;Keski-Rahkonen, A.;Rose, R. J.;Pulkkinen, L.;Rissanen, A.;Silventoinen, K.
通讯作者：
Silventoinen, K.
DOI：
10.1002/j.1550-8528.1997.tb00559.x
发表时间：
1997-07-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Austin, MA;Friedlander, Y;King, MC
通讯作者：
King, MC
影响因子：
1.9
作者：
Lee, Juan;Chen, Li;Hu, Yong H.
通讯作者：
Hu, Yong H.
影响因子：
0.9
作者：
Estourgie-van Burk, G. Frederiek;Bartels, Meike;Boomsma, Dorret I.
通讯作者：
Boomsma, Dorret I.
影响因子：
--
作者：
Manek, NJ;Hart, D;MacGregor, AJ
通讯作者：
MacGregor, AJ