Neural evidence for recognition of naturalistic videos in monkey hippocampus.
Neural evidence for recognition of naturalistic videos in monkey hippocampus.
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DOI：
10.1002/hipo.23335
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发表时间：
2021-08
期刊：
影响因子：
3.5
通讯作者：
Suzuki WA
中科院分区：
文献类型：
--
作者：
Sakon JJ;Suzuki WA
海马体在识别记忆中的作用长期以来一直是争论的焦点。用于研究认知的任务通常需要明确的探测，参与者必须做出反应以证明他们记得，但在海马区参与的问题上产生了喜忧参半的结果。在这里，我们让猴子自由观看自然主义视频，并只通过观看两个单独的小说v重复视频条件来测试它们的记忆。值得注意的是，很大比例(30%)的海马神经元通过放电频率的变化来区分这些视频，这些变化与它们在屏幕上呈现的持续时间有关，而不是像工作记忆所预期的那样，在它们之间的延迟期内。这些单一神经元中的许多(15%)对两种检索条件都有贡献，并在具有试验独特内容的试验中区分新视频和重复视频，这表明它们可以检测到熟悉性。与新的视频相比，大多数参与分类器的神经元在重复视频时表现出放电频率的增强，这一模式以前从未在海马体中表现出来。这些结果表明，海马体通过在自由观看时的熟悉程度来促进识别记忆。
The role of the hippocampus in recognition memory has long been a source of debate. Tasks used to study recognition that typically require an explicit probe, where the participant must make a response to prove they remember, yield mixed results on hippocampal involvement. Here, we tasked monkeys to freely view naturalistic videos, and only tested their memory via looking times for two separate novel v. repeat video conditions on each trial. Notably, a large proportion (>30%) of hippocampal neurons differentiated these videos via changes in firing rates time-locked to the duration of their presentation on screen, and not during the delay period between them as would be expected for working memory. Many of these single neurons (>15%) contributed to both retrieval conditions, and differentiated novel from repeat videos across trials with trial-unique content, suggesting they detect familiarity. The majority of neurons contributing to the classifier showed an enhancement in firing rate on repeat compared to novel videos, a pattern which has not previously been shown in hippocampus. These results suggest the hippocampus contributes to recognition memory via familiarity during free-viewing.
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发表时间：
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期刊：
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影响因子：
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发表时间：
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DOI：
10.1016/j.cub.2010.01.053
发表时间：
2010-03-23
期刊：
Current biology : CB
影响因子：
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