Cancer-targeted optical imaging with fluorescent zinc oxide nanowires.

Cancer-targeted optical imaging with fluorescent zinc oxide nanowires.
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DOI:
10.1021/nl201782m
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发表时间:
2011-09-14
期刊:
影响因子:
10.8
通讯作者:
Cai W
Cai W
中科院分区:
材料科学1区
文献类型:
--
作者:
Hong H;Shi J;Yang Y;Zhang Y;Engle JW;Nickles RJ;Wang X;Cai W

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Herein we demonstrate that intrinsically fluorescent zinc oxide (ZnO) nanowires (NWs) can be adopted for molecularly targeted imaging of cancer cells, after they are functionalized to render water solubility, biocompatibility, and low cellular toxicity. Optical imaging of integrin αvβ3 on U87MG human glioblastoma cells was achieved with RGD peptide-conjugated green fluorescent ZnO NWs, which opened up new avenues of research for investigating ZnO NW-based agents in tumor vasculature-targeted molecular imaging and drug delivery.
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