Early life bisphenol A exposure and neurobehavior at 8years of age: Identifying windows of heightened vulnerability.
Early life bisphenol A exposure and neurobehavior at 8years of age: Identifying windows of heightened vulnerability.
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年龄8岁的早期双胞胎酚A暴露和神经行为：确定脆弱性的窗户。
DOI：
10.1016/j.envint.2017.07.021
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发表时间：
2017-10
影响因子：
11.8
通讯作者：
Braun JM
中科院分区：
文献类型：
--
作者：
Stacy SL;Papandonatos GD;Calafat AM;Chen A;Yolton K;Lanphear BP;Braun JM
早期的BPA暴露可能会影响神经行为，但很少有研究调查胎儿或儿童是否在发育期更容易受到这些潜在影响。我们在来自俄亥俄州辛辛那提的228名母亲及其子女的多种族队列中探索了BPA暴露的脆弱性窗口。我们测量了从怀孕第二个三个月到孩子8岁的两个产前和六个产后时间点的尿BPA浓度。在8岁时，我们进行了儿童行为评估系统-2（BASC-2）、执行功能行为评定量表和儿童韦氏智力量表-IV。我们使用旨在识别更高脆弱性窗口的多信息人模型估计了每个工具综合得分的协变量调整差异。在所有儿童中，没有强有力的证据表明BPA和神经行为之间的关联因暴露时间而异（访视× BPA p值=0.16）。然而，儿童性别改变了重复BPA测量与BASC-2评分的相关性（访视×性别× BPA p值=0.02-0.23）。例如，产前BPA每增加10倍，女孩的外向行为就更多（β=6.2，95% CI：0.8，11.6），而男孩则不然（β=-0.8，95% CI：-5.0，3.4）。相比之下，8年BPA增加10倍与男孩更多的外在行为相关（β=3.9，95% CI：0.6，7.2），但与女孩无关（β=0.3，95% CI：-3.5，4.1）。我们发现，BPA和儿童神经行为之间的性别依赖性关联可能取决于BPA暴露的时间。
Early life BPA exposure could affect neurobehavior, but few studies have investigated whether there are developmental periods when the fetus or child is more vulnerable to these potential effects. We explored windows of vulnerability to BPA exposure in a multiethnic cohort of 228 mothers and their children from Cincinnati, Ohio. We measured urinary BPA concentrations at up to two prenatal and six postnatal time points from the 2nd trimester of pregnancy until the child was age 8 years. At age 8 years, we administered the Behavioral Assessment System for Children-2 (BASC-2), Behavior Rating Inventory of Executive Function, and Wechsler Intelligence Scale for Children-IV. We estimated covariate-adjusted differences in composite scores from each instrument using a multiple informant model designed to identify heightened windows of vulnerability. Among all children, there was not strong evidence that the associations between BPA and neurobehavior varied by the timing of exposure (Visit × BPA p-values=0.16). However, child sex modified the associations of repeated BPA measures with BASC-2 scores (Visit × Sex × BPA p-values=0.02–0.23). For example, each 10-fold increase in prenatal BPA was associated with more externalizing behaviors in girls (β=6.2, 95% CI: 0.8, 11.6), but not boys (β=−0.8, 95% CI: −5.0, 3.4). In contrast, a 10-fold increase in 8-year BPA was associated with more externalizing behaviors in boys (β=3.9, 95% CI: 0.6, 7.2), but not girls (β=0.3, 95% CI: −3.5, 4.1). We found that sex-dependent associations between BPA and child neurobehavior may depend on the timing of BPA exposure.
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影响因子：
3.4
作者：
Evans, Sarah F.;Kobrosly, Roni W.;Barrett, Emily S.;Thurston, Sally W.;Calafat, Antonia M.;Weiss, Bernard;Stahlhut, Richard;Yolton, Kimberly;Swan, Shanna H.
通讯作者：
Swan, Shanna H.
在美国生产和使用BPA的行业工人中，尿型双酚A（BPA）浓度。
影响因子：
2.6
作者：
Hines CJ;Jackson MV;Deddens JA;Clark JC;Ye X;Christianson AL;Meadows JW;Calafat AM
通讯作者：
Calafat AM
影响因子：
11.4
作者：
Hehn, Rebecca Simonne
通讯作者：
Hehn, Rebecca Simonne
影响因子：
7.6
作者：
Hong, Soon-Beom;Hong, Yun-Chul;Cho, Soo-Churl
通讯作者：
Cho, Soo-Churl
影响因子：
10.4
作者：
Bellinger DC
通讯作者：
Bellinger DC