Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression.
Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression.
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DOI：
10.1186/bcr1746
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Coussens LM
中科院分区：
文献类型：
--
作者：
DeNardo DG;Coussens LM
最近对癌症发展的分子和细胞机制的深入研究表明，免疫细胞在功能上调节上皮性癌症的发展和进展。此外，积累的临床和实验数据表明，对进化的乳腺肿瘤的免疫反应的结果在很大程度上取决于所引发的免疫反应的类型。包括细胞溶解T淋巴细胞在内的急性肿瘤导向免疫反应似乎可以防止肿瘤的发展，而包括慢性体液免疫激活、Th2细胞浸润和原肿瘤极化先天炎症细胞在内的免疫反应可以促进肿瘤的发展和疾病的进展。在此，我们回顾了这一文献，并总结了重要的新发现，揭示了先天白细胞和适应性白细胞作为乳腺癌发生调节因子的矛盾作用。
Recent insights into the molecular and cellular mechanisms underlying cancer development have revealed that immune cells functionally regulate epithelial cancer development and progression. Moreover, accumulated clinical and experimental data indicate that the outcome of an immune response toward an evolving breast neoplasm is largely determined by the type of immune response elicited. Acute tumor-directed immune responses involving cytolytic T lymphocytes appear to protect against tumor development, whereas immune responses involving chronic activation of humoral immunity, infiltration by Th2 cells, and protumor-polarized innate inflammatory cells result in the promotion of tumor development and disease progression. Herein we review this body of literature and summarize important new findings revealing the paradoxical role of innate and adaptive leukocytes as regulators of breast carcinogenesis.
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影响因子：
10.5
作者：
Coussens, LM;Raymond, WW;Hanahan, D
通讯作者：
Hanahan, D
影响因子：
4.4
作者：
Almand, B;Clark, JI;Gabrilovich, DI
通讯作者：
Gabrilovich, DI
影响因子：
3.2
作者：
Benítez-Bribiesca, L;Wong, A;Castellanos, E
通讯作者：
Castellanos, E
影响因子：
3.1
作者：
Chen, WJ
通讯作者：
Chen, WJ
DOI：
10.1038/sj.neo.7900054
发表时间：
1999-11-01
期刊：
Neoplasia (New York)
影响因子：
--
作者：
Barbera-Guillem, Emilio;May, Kenneth F., Jr.;Nelson, M. Bud
通讯作者：
Nelson, M. Bud