Relationship Between Body Composition and Death in Patients with COVID-19 Differs Based on the Presence of Gastrointestinal Symptoms.
Relationship Between Body Composition and Death in Patients with COVID-19 Differs Based on the Presence of Gastrointestinal Symptoms.
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DOI：
10.1007/s10620-021-07324-4
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发表时间：
2022-09
影响因子：
3.1
通讯作者：
Freedberg DE
中科院分区：
文献类型：
--
作者：
Nobel YR;Su SH;Anderson MR;Luk L;Small-Saunders JL;Reyes-Soffer G;Gallagher D;Freedberg DE
出现胃肠道症状的 SARS-CoV-2 患者比没有出现胃肠道症状的患者临床病程更轻。严重 COVID-19 疾病的危险因素包括肥胖和肌肉减少症增加。确定身体成分危险因素是否与胃肠道症状患者的较差预后相关。这是一项对住院的 COVID-19 患者进行的回顾性研究，这些患者接受了腹部 CT 扫描以了解临床指征。收集腹部身体成分测量，包括骨骼肌指数（SMI）、肌内脂肪组织指数（IMATI）、内脏脂肪组织指数（VATI）、皮下脂肪组织指数（SATI）、内脏与皮下脂肪组织比率（VAT/SAT比率）以及肝脏和脾脏衰减。对 SARS-CoV-2 检测呈阳性时有或没有胃肠道症状的患者的身体成分测量值与 30 天死亡率之间的关联进行了评估。对 190 名 COVID-19 患者的腹部 CT 扫描进行了评估。 117 例 (62%) 出现胃肠道症状，包括恶心、呕吐、腹泻或腹痛。在没有胃肠道症状的患者中，死亡患者的 IMATI 较高（p = 0.049），SMI 较低（p = 0.010），并且 VAT/SAT 比率有较高的趋势。在有胃肠道症状的患者中，死亡患者的 IMATI 显着升高（p = 0.025），但其他指标没有差异。在 COVID-19 患者中，没有胃肠道症状的患者显示出死亡率与低 SMI、高 IMATI 以及较高 VAT/SAT 比率趋势之间的预期关联，但有胃肠道症状的患者却没有。未来的研究应探讨出现胃肠道症状的 COVID-19 患者病程改变的机制。在线版本包含可在 10.1007/s10620-021-07324-4 获取的补充材料。
Patients with SARS-CoV-2 who present with gastrointestinal symptoms have a milder clinical course than those who do not. Risk factors for severe COVID-19 disease include increased adiposity and sarcopenia. To determine whether body composition risk factors are associated with worse outcomes among patients with gastrointestinal symptoms. This was a retrospective study of hospitalized patients with COVID-19 who underwent abdominal CT scan for clinical indications. Abdominal body composition measures including skeletal muscle index (SMI), intramuscular adipose tissue index (IMATI), visceral adipose tissue index (VATI), subcutaneous adipose tissue index (SATI), visceral-to-subcutaneous adipose tissue ratio (VAT/SAT ratio), and liver and spleen attenuation were collected. The association between body composition measurements and 30-day mortality was evaluated in patients with and without gastrointestinal symptoms at the time of positive SARS-CoV-2 test. Abdominal CT scans of 190 patients with COVID-19 were evaluated. Gastrointestinal symptoms including nausea, vomiting, diarrhea, or abdominal pain were present in 117 (62%). Among patients without gastrointestinal symptoms, those who died had greater IMATI (p = 0.049), less SMI (p = 0.010), and a trend toward a greater VAT/SAT ratio. Among patients with gastrointestinal symptoms, those who died had significantly greater IMATI (p = 0.025) but no differences in other measures. Among patients with COVID-19, those without gastrointestinal symptoms showed the expected associations between mortality and low SMI, high IMATI, and trend toward higher VAT/SAT ratio, but those with gastrointestinal symptoms did not. Future studies should explore the mechanisms for the altered disease course in patients with COVID-19 who present with gastrointestinal symptoms. The online version contains supplementary material available at 10.1007/s10620-021-07324-4.
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影响因子：
2.2
作者：
Aziz M;Haghbin H;Lee-Smith W;Goyal H;Nawras A;Adler DG
通讯作者：
Adler DG
DOI：
10.1111/apha.12224
发表时间：
2014-03
期刊：
Acta physiologica (Oxford, England)
影响因子：
--
作者：
Aubrey J;Esfandiari N;Baracos VE;Buteau FA;Frenette J;Putman CT;Mazurak VC
通讯作者：
Mazurak VC
影响因子：
10
作者：
Anderson MR;Easthausen I;Gallagher G;Udupa J;Tong Y;Torigian D;Diamond JM;Porteous MK;Palmer SM;Snyder LD;Benvenuto L;Aversa M;Arcasoy S;Greenland JR;Hays SR;Kukreja J;Cantu E;Kim JS;Gallagher D;Baldwin MR;Barr RG;Lederer DJ;Christie JD;Singer JP
通讯作者：
Singer JP
影响因子：
4.9
作者：
Irlbeck, T.;Massaro, J. M.;Bamberg, F.;O'Donnell, C. J.;Hoffmann, U.;Fox, C. S.
通讯作者：
Fox, C. S.
DOI：
10.1097/meg.0000000000001583
发表时间：
2020-06-01
影响因子：
2.1
作者：
Al-Azzawi, Yasir;Albo, Betty;Szabo, Gyongyi
通讯作者：
Szabo, Gyongyi