Skeletal muscle adiposity and outcomes in candidates for lung transplantation: a lung transplant body composition cohort study.

Skeletal muscle adiposity and outcomes in candidates for lung transplantation: a lung transplant body composition cohort study.
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DOI:
10.1136/thoraxjnl-2019-214461
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发表时间:
2020-09
期刊:
影响因子:
10
通讯作者:
Singer JP
Singer JP
中科院分区:
医学1区
文献类型:
--
作者:
Anderson MR;Easthausen I;Gallagher G;Udupa J;Tong Y;Torigian D;Diamond JM;Porteous MK;Palmer SM;Snyder LD;Benvenuto L;Aversa M;Arcasoy S;Greenland JR;Hays SR;Kukreja J;Cantu E;Kim JS;Gallagher D;Baldwin MR;Barr RG;Lederer DJ;Christie JD;Singer JP

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CT measurement of body composition may improve lung transplant candidate selection. We assessed whether skeletal muscle adipose deposition on abdominal and thigh CT scans was associated with 6 min walk distance (6MWD) and wait-list survival in lung transplant candidates. Each ½-SD decrease in abdominal muscle attenuation (indicating greater lipid content) was associated with 14 m decrease in 6MWD (95% CI −20 to −8) and 20% increased risk of death or delisting (95% CI 10% to 40%). Each ½-standard deviation decrease in thigh muscle attenuation was associated with 15 m decrease in 6MWD (95% CI −21 to −10). CT imaging may improve candidate risk stratification.
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