Age-related changes in place learning for adjacent and separate locations.
Age-related changes in place learning for adjacent and separate locations.
复制标题
DOI：
10.1016/j.neurobiolaging.2013.03.033
复制
发表时间：
2013-10
影响因子：
4.2
通讯作者：
Gilbert PE
中科院分区：
文献类型：
--
作者：
Gracian EI;Shelley LE;Morris AM;Gilbert PE
研究了空间干扰对年轻大鼠和老年大鼠位置学习的影响。大鼠被训练在一个放射状的八臂迷宫中，以区分奖励臂和非奖励臂，这些手臂要么是彼此相邻的（高空间干扰），要么是被两个手臂位置的距离分开的（低空间干扰）。每只大鼠在连续两天的10次试验中达到9次正确选择的标准。数据显示，当手臂相邻且空间干扰高时，老年大鼠比年轻大鼠犯了更多的错误。然而，当手臂分开且空间干扰较低时，没有发现组间差异。在两种情况下，达到学习标准所需的试验次数也没有发现组间差异。结果表明，与年龄相关的大脑变化导致位置学习中的错误增加，特别是当空间干扰高时，这表明空间模式分离在老年动物中可能效率较低。
The effect of spatial interference on place learning was examined in young and old rats. Rats were trained on a radial eight-arm maze to discriminate between a reward arm and a non-reward arm that either were adjacent to one another (high spatial interference) or separated by a distance of two arm positions (low spatial interference). Each rat was tested until reaching a criterion of nine correct choices out of 10 trials across two consecutive days. The data revealed that old rats committed significantly more errors than young rats when the arms were adjacent and spatial interference was high. However, no group differences were detected when the arms were separated and spatial interference was low. Group differences also were not detected in the number of trials required to reach the learning criterion in either condition. The results indicate that age-related brain changes result in increased errors during place learning, particularly when spatial interference is high, suggesting that spatial pattern separation may be less efficient in aged animals.
登录
查看更多内容
影响因子：
3.5
作者：
Duff, Melissa C.;Warren, David E.;Gupta, Rupa;Vidal, Juan Pablo Benabe;Tranel, Daniel;Cohen, Neal J.
通讯作者：
Cohen, Neal J.
影响因子：
3.3
作者：
Driscoll, I.;Howard, S. R.;Sutherland, R. J.
通讯作者：
Sutherland, R. J.
影响因子：
1.9
作者：
Goodrich-Hunsaker, Naomi J.;Hunsaker, Michael R.;Kesner, Raymond P.
通讯作者：
Kesner, Raymond P.
使用高分辨率功能磁共振成像对人类内侧颞叶进行成像。
影响因子：
16.2
作者：
Carr, Valerie A.;Rissman, Jesse;Wagner, Anthony D.
通讯作者：
Wagner, Anthony D.
影响因子：
9.9
作者：
Driscoll, I.;Davatzikos, C.;Resnick, S. M.
通讯作者：
Resnick, S. M.