Cross-kingdom interactions: Candida albicans and bacteria.
Cross-kingdom interactions: Candida albicans and bacteria.
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DOI：
10.1111/j.1574-6968.2009.01668.x
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发表时间：
2009-10
影响因子：
2.1
通讯作者：
Jabra-Rizk MA
中科院分区：
文献类型：
--
作者：
Shirtliff ME;Peters BM;Jabra-Rizk MA
细菌和真菌一起发现在无数的环境中，特别是在生物膜中，附着的物种通过不同的信号机制相互作用。然而，尽管存在了数十亿年，探索真菌-细菌相互作用的研究领域，特别是在多菌感染的背景下，仍处于初级阶段。然而，描述真菌病原体白色念珠菌与各种细菌病原体之间广泛相互作用的报道正在增加。互利相互作用的一个例子是共聚集，这一现象发生在口腔生物膜中，白色念珠菌与口腔细菌的粘附性被认为对其在口腔的定植至关重要。相比之下，白色念珠菌和铜绿假单胞菌之间的相互作用被描述为竞争和拮抗性质的。另一个有趣的相互作用是发生在金黄色葡萄球菌和白色念珠菌之间的相互作用，虽然还没有完全描述，但似乎是最初的协同作用。这些不同和重要的病原体之间的复杂相互作用，如果发生在免疫受损的宿主身上，将具有重大的临床意义。因此，了解真菌-细菌相互作用中的黏附和信号转导机制可能有助于开发新的治疗策略来阻止微生物定植和多菌疾病的发展。
Bacteria and fungi are found together in a myriad of environments and particularly in a biofilm, where adherent species interact through diverse signaling mechanisms. Yet, despite billions of years of coexistence, the area of research exploring fungal–bacterial interactions, particularly within the context of polymicrobial infections, is still in its infancy. However, reports describing a multitude of wide-ranging interactions between the fungal pathogen Candida albicans and various bacterial pathogens are on the rise. An example of a mutually beneficial interaction is coaggregation, a phenomenon that takes place in oral biofilms where the adhesion of C. albicans to oral bacteria is considered crucial for its colonization of the oral cavity. In contrast, the interaction between C. albicans and Pseudomonas aeruginosa is described as being competitive and antagonistic in nature. Another intriguing interaction is that occurring between Staphylococcus aureus and C. albicans, which although not yet fully characterized, appears to be initially synergistic. These complex interactions between such diverse and important pathogens would have significant clinical implications if they occurred in an immunocompromised host. Therefore, understanding the mechanisms of adhesion and signaling involved in fungal–bacterial interactions may lead to the development of novel therapeutic strategies for impeding microbial colonization and development of polymicrobial disease.
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影响因子：
3.1
作者：
CARLSON, E
通讯作者：
CARLSON, E
影响因子：
4.9
作者：
Jabra-Rizk, MA;Meiller, TF;Shirtliff, ME
通讯作者：
Shirtliff, ME
影响因子：
4
作者：
El-Azizi, MA;Starks, SE;Khardori, N
通讯作者：
Khardori, N
影响因子：
1.7
作者：
Costerton, JW;Montanaro, L;Arciola, CR
通讯作者：
Arciola, CR
影响因子：
--
作者：
Grimaudo, NJ;Nesbitt, WE
通讯作者：
Nesbitt, WE