Associations of Electronic Cigarette Nicotine Concentration With Subsequent Cigarette Smoking and Vaping Levels in Adolescents.
Associations of Electronic Cigarette Nicotine Concentration With Subsequent Cigarette Smoking and Vaping Levels in Adolescents.
复制标题
电子香烟尼古丁浓度与随后的香烟吸烟和青少年烟的关联。
DOI：
10.1001/jamapediatrics.2017.3209
复制
发表时间：
2017-12-01
期刊：
影响因子：
26.1
通讯作者：
Barrington-Trimis JL
中科院分区：
文献类型：
--
作者：
Goldenson NI;Leventhal AM;Stone MD;McConnell RS;Barrington-Trimis JL
研究表明，青少年使用电子烟（vaping）与可燃香烟吸烟的开始和发展有关，但这种关联的原因尚不清楚。评估使用尼古丁浓度较高的电子烟是否与随后吸烟和吸电子烟的频率和强度增加有关。未来的学校队列;在2015年春季（基线，10年级）和秋季（6个月随访，11年级）对过去30天的电子烟使用者进行了调查，其中有来自加利福尼亚州洛杉矶大都市区10所高中的尼古丁浓度数据（N=181）。基线电子烟尼古丁浓度的自我报告（即，无[0 mg/mL]、低[1-5 mg/mL]、中[6-17 mg/mL]或高[18 mg/mL或更高]）。6个月随访时，过去30天吸烟和使用电子烟的频率（0天[无]、1-2天[不频繁]、≥ 3天[频繁]）以及每日吸烟和吸电子烟强度（每天吸烟的香烟数量、每天吸电子烟的次数和每次吸电子烟的抽吸次数）。基线电子烟尼古丁浓度vaped和频繁（与没有）过去30天可燃香烟和电子烟使用之间存在正相关。尼古丁浓度的每次连续增加（从无到低，从低到中，从中到高）与频繁吸烟和吸电子烟的几率分别增加2.26（95%置信区间[CI]：1.28，3.98）和1.65（95%CI：1.09，2.51）相关，在调整吸烟和吸电子烟的基线频率和其他相关协变量后。使用高尼古丁浓度电子烟（与无尼古丁浓度电子烟相比）与随访时每天吸烟数量增加相关（校正率比[95%CI] = 7.03 [6.11，7.95]）。使用低、中和高尼古丁浓度（与无尼古丁相比）与随访时每天吸烟次数（调整后的比率：2.44-3.32）和每次吸烟次数（调整后的比率：2.05-3.39）显著增加相关（ps<.05）。这项研究的结果提供了初步证据，表明年轻人使用尼古丁浓度较高的电子烟可能会增加吸烟和吸电子烟的频率和强度。
Research indicates that e-cigarette use (vaping) among adolescents is associated with the initiation and progression of combustible cigarette smoking, yet the reasons for this association are unknown. To evaluate whether use of e-cigarettes with higher nicotine concentrations is associated with subsequent increases in the frequency and intensity of combustible cigarette smoking and vaping. Prospective school-based cohort; surveys were administered in Spring (baseline, 10th grade) and Fall (6-month follow-up, 11th grade) 2015 among past 30-day vapers with available nicotine concentration data (N=181) from 10 high schools in the Los Angeles, CA metropolitan area. Self-report of baseline e-cigarette nicotine concentration (i.e., none [0 mg/mL], low [1–5 mg/mL], medium [6–17 mg/mL] or high [18 mg/mL or greater]) typically used during the past 30-days. Frequency of past 30-day combustible cigarette smoking and e-cigarette use (0 days [none], 1–2 days [infrequent], ≥ 3 days [frequent]) and daily smoking and vaping intensity (number of cigarettes smoked per day, number of vaping episodes per day and number of puffs per vaping episode) at 6-month follow-up. There were positive associations between baseline e-cigarette nicotine concentration vaped and frequent (vs. no) past 30-day combustible cigarette and e-cigarette use at follow-up. Each successive increase in nicotine concentration (none-to-low, low-to-medium, medium-to-high) was associated with a 2.26 (95% confidence interval [CI]: 1.28, 3.98) and 1.65 (95%CI: 1.09, 2.51) increase in odds of frequent smoking and vaping, respectively, after adjustment for baseline frequency of smoking and vaping and other relevant covariates. Use of high (vs. no) nicotine concentration e-cigarettes was associated with a greater number of cigarettes smoked/day at follow-up (adjusted rate ratio [95%CI] = 7.03 [6.11, 7.95]). Use of low, medium and high nicotine concentrations (vs. no nicotine) were associated with a significantly greater number of vaping episodes per day (adjusted rate ratios: 2.44–3.32) and number of puffs per vaping episode (adjusted rate ratios: 2.05–3.39) at follow-up (ps<.05). The results of this study provide preliminary evidence that use of e-cigarettes with higher nicotine concentrations by youth may increase the frequency and intensity of smoking and vaping.
登录
查看更多内容
影响因子：
5.2
作者：
Miech, Richard;Patrick, Megan E.;Johnston, Lloyd D.
通讯作者：
Johnston, Lloyd D.
电子烟的使用与青春期早期燃烧烟草产品吸烟的启动。
DOI：
10.1001/jama.2015.8950
发表时间：
2015-08-18
期刊：
JAMA
影响因子：
--
作者：
Leventhal AM;Strong DR;Kirkpatrick MG;Unger JB;Sussman S;Riggs NR;Stone MD;Khoddam R;Samet JM;Audrain-McGovern J
通讯作者：
Audrain-McGovern J
影响因子：
3.4
作者：
Dawkins, Lynne E.;Kimber, Catherine F.;Corcoran, Olivia
通讯作者：
Corcoran, Olivia
影响因子：
6
作者：
Helen, Gideon St.;Havel, Christopher;Benowitz, Neal L.
通讯作者：
Benowitz, Neal L.
影响因子：
4.7
作者：
Goniewicz, Maciej L.;Kuma, Tomasz;Kosmider, Leon
通讯作者：
Kosmider, Leon