Immunophenotyping of compound and spitz nevi and vertical growth-phase melanomas using a panel of monoclonal antibodies reactive in paraffin sections.

Immunophenotyping of compound and spitz nevi and vertical growth-phase melanomas using a panel of monoclonal antibodies reactive in paraffin sections.
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使用一组在石蜡切片中具有反应性的单克隆抗体对化合物、斯皮茨痣和垂直生长期黑色素瘤进行免疫表型分析。

DOI:
10.1111/1523-1747.ep12470206
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发表时间:
1993
期刊:
The Journal of investigative dermatology
影响因子:
--
通讯作者:
Johnson,B
Johnson,B
中科院分区:
--
文献类型:
--
作者:
Lazzaro,B;Elder,DE;Rebers,A;Power,L;Herlyn,M;Menrad,A;Johnson,B

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材料与方法从宾夕法尼亚大学医院皮肤病理科的患者档案中随机选择16例Spitz痣、15例复合痣和20例具有垂直生长期的恶性黑色素瘤的典型病例。已收到标本用于福尔马林中的病理诊断,并常规处理成石蜡块。斯皮茨痣或复合痣在显微镜下均无发育异常成分。黑色素瘤均处于垂直生长期,为Clark III级或IV级[22]。
MATERIALS AND METHODSCharacteristic examples of 16 Spitz nevi, 15 compound nevi, and 20 malignant melanomas with vertical growth phase were chosen randomly from patient files in the Section of Dermatopathology, Hospital of the University of Pennsylvania. The specimens had been received for pathologic diagnosis in formalin and routinely processed into paraffin blocks. None of the Spitz or compound nevi had a microscopically dysplastic component. The melanomas were all in vertical growth phase, either Clark’s level III or IV [22].
与黑色素瘤肿瘤进展早期相关的抗原的分子克隆和表征。
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