Roles for the pre-supplementary motor area and the right inferior frontal gyrus in stopping action: electrophysiological responses and functional and structural connectivity.
Roles for the pre-supplementary motor area and the right inferior frontal gyrus in stopping action: electrophysiological responses and functional and structural connectivity.
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DOI：
10.1016/j.neuroimage.2011.09.049
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发表时间：
2012-02-01
期刊：
影响因子：
5.7
通讯作者：
Tandon, Nitin
中科院分区：
文献类型：
--
作者：
Swann, Nicole C.;Cai, Weidong;Conner, Christopher R.;Pieters, Thomas A.;Claffey, Michael P.;George, Jobi S.;Aron, Adam R.;Tandon, Nitin
关键词：
前补充运动区（preSMA）和右额下回（rIFG）对于完全停止动作都很重要。这些区域在准备停止时也参与其中。我们的目的是阐明这些区域的作用，利用高时空分辨率的皮层电图（ECoG），并通过使用一个任务，从事准备停止和完全停止。首先，我们在16名健康对照参与者中使用fMRI验证了任务，以确认preSMA和rIFG都是活跃的。接下来，我们研究了一个罕见的患者与颅内网格覆盖这两个地区，使用宏刺激，弥散纤维束成像，皮质-皮质诱发电位（CCEP）和基于任务的皮层脑电图。对preSMA的宏观刺激诱导行为运动停止。弥散纤维束成像显示了前SMA和rIFG之间的结构连接。CCEP分析表明，刺激前SMA在rIFG中在30 ms内诱发强电位。在任务过程中，当准备停止时，两个区域的高伽马振幅（~70-250 Hz）增加，preSMA先于rIFG约750 ms。对于完全停止，两个区域的高伽马振幅也增加，同样preSMA先于rIFG。此外，在停止时，两个区域中的β带活动（~16 Hz）增加，成功与不成功的停止试验具有显著更强的长程相干性。这些结果补充了先前关于preSMA和rIFG之间的结构/功能作用控制网络的报道。他们进一步揭示了高伽马波段准备停止和完全停止时区域间的时间差异。他们还揭示了强大的区域间的连贯性时，停止是成功的β带。行动控制理论的影响进行了讨论。
Both the pre-supplementary motor area (preSMA) and the right inferior frontal gyrus (rIFG) are important for stopping action outright. These regions are also engaged when preparing to stop. We aimed to elucidate the roles of these regions by harnessing the high spatio-temporal resolution of electrocorticography (ECoG), and by using a task that engages both preparing to stop and stopping outright. First, we validated the task using fMRI in 16 healthy control participants to confirm that both the preSMA and the rIFG were active. Next, we studied a rare patient with intracranial grid coverage of both these regions, using macrostimulation, diffusion tractography, cortico-cortical evoked potentials (CCEPs) and task-based ECoG. Macrostimulation of the preSMA induced behavioral motor arrest. Diffusion tractography revealed a structural connection between the preSMA and rIFG. CCEP analysis showed that stimulation of the preSMA evoked strong potentials within 30 ms in rIFG. During the task, when preparing to stop, there was increased high gamma amplitude (~70–250 Hz) in both regions, with preSMA preceding rIFG by ~750 ms. For outright stopping there was also a high gamma amplitude increase in both regions, again with preSMA preceding rIFG. Further, at the time of stopping, there was an increase in beta band activity (~16 Hz) in both regions, with significantly stronger long-range coherence for successful vs. unsuccessful stop trials. The results complement earlier reports of a structural/functional action control network between the preSMA and rIFG. They go further by revealing between-region timing differences in the high gamma band when preparing to stop and stopping outright. They also reveal strong between-region coherence in the beta band when stopping is successful. Implications for theories of action control are discussed.
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影响因子：
5.7
作者：
Boehler, C. N.;Appelbaum, L. G.;Krebs, R. M.;Hopf, J. M.;Woldorff, M. G.
通讯作者：
Woldorff, M. G.
DOI：
10.1073/pnas.96.14.8301
发表时间：
1999-07-06
影响因子：
11.1
作者：
Garavan, H;Ross, TJ;Stein, EA
通讯作者：
Stein, EA
影响因子：
4.8
作者：
Chevrier, Andre D.;Noseworthy, Michael D.;Schachar, Russell
通讯作者：
Schachar, Russell
影响因子：
3.2
作者：
Chambers, CD;Bellgrove, MA;Mattingley, JB
通讯作者：
Mattingley, JB
影响因子：
5.7
作者：
Beckmann, CF;Jenkinson, M;Smith, SM
通讯作者：
Smith, SM