Essential oils loaded in nanosystems: a developing strategy for a successful therapeutic approach.
Essential oils loaded in nanosystems: a developing strategy for a successful therapeutic approach.
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DOI：
10.1155/2014/651593
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Bergonzi MC
中科院分区：
文献类型：
--
作者：
Bilia AR;Guccione C;Isacchi B;Righeschi C;Firenzuoli F;Bergonzi MC
精油是多种挥发性分子的复杂混合物，如萜类化合物、酚衍生的芳香成分和脂肪族成分，在制药、卫生、化妆品、农业和食品工业中有着浓厚的兴趣。自中世纪以来，精油已被广泛用于杀菌、杀病毒、杀真菌、抗寄生虫、杀虫和其他药用特性，如镇痛、镇静、抗炎、解痉和局部麻醉。在这篇综述中，他们的纳米胶囊在药物传递系统中被提出，因为他们能够通过维持治疗效果来降低挥发性，提高稳定性，水溶性和精油基制剂的功效。可以提出两类纳米载体：聚合物纳米颗粒制剂，广泛研究并显著改善了精油的抗菌活性；脂质载体，包括脂质体、固体脂质纳米颗粒、纳米结构脂质颗粒以及纳米和微乳液。此外，环糊精包合物等分子配合物也代表了提高精油水溶性、稳定性和生物利用度以及降低挥发性的有效策略。
Essential oils are complex blends of a variety of volatile molecules such as terpenoids, phenol-derived aromatic components, and aliphatic components having a strong interest in pharmaceutical, sanitary, cosmetic, agricultural, and food industries. Since the middle ages, essential oils have been widely used for bactericidal, virucidal, fungicidal, antiparasitical, insecticidal, and other medicinal properties such as analgesic, sedative, anti-inflammatory, spasmolytic, and locally anaesthetic remedies. In this review their nanoencapsulation in drug delivery systems has been proposed for their capability of decreasing volatility, improving the stability, water solubility, and efficacy of essential oil-based formulations, by maintenance of therapeutic efficacy. Two categories of nanocarriers can be proposed: polymeric nanoparticulate formulations, extensively studied with significant improvement of the essential oil antimicrobial activity, and lipid carriers, including liposomes, solid lipid nanoparticles, nanostructured lipid particles, and nano- and microemulsions. Furthermore, molecular complexes such as cyclodextrin inclusion complexes also represent a valid strategy to increase water solubility and stability and bioavailability and decrease volatility of essential oils.
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