Integrated optical- and acoustic-resolution photoacoustic microscopy based on an optical fiber bundle.

Integrated optical- and acoustic-resolution photoacoustic microscopy based on an optical fiber bundle.
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DOI:
10.1364/ol.38.000052
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发表时间:
2013-01-01
期刊:
影响因子:
3.6
通讯作者:
Wang LV
Wang LV
中科院分区:
物理与天体物理2区
文献类型:
--
作者:
Xing W;Wang L;Maslov K;Wang LV

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光声显微技术近年来取得了很大的发展,其空间分辨率和最大成像深度都是可调节的。然而,每个PAM系统目前仅实现一种分辨率和相关的最大成像深度。在这里,我们提出了一个集成的光学分辨率(OR)和声学分辨率(AR)PAM系统,通过光纤束传输光来实现。单个光纤芯用于递送用于OR照明的光,以便实现小的光斑尺寸并因此实现高的横向分辨率,而所有光纤芯用于递送用于AR照明的更多能量。大多数其他组件由OR和AR成像共享。当最大成像深度在1.3 mm和3.0 mm之间切换时,横向分辨率可以在2.2 μm和40 μm之间无缝切换。该系统可以自动共配准更高分辨率的OR和更深的AR光声成像。
Photoacoustic microscopy (PAM), whose spatial resolution and maximum imaging depth are both scalable, has made great progress in recent years. However, each PAM system currently achieves only one resolution with an associated maximum imaging depth. Here, we present an integrated optical-resolution (OR) and acoustic-resolution (AR) PAM system implemented by delivering light via an optical fiber bundle. A single fiber core is used to deliver light for OR illumination in order to achieve a small spot size and hence high lateral resolution, whereas all the fiber cores are used to deliver more energy for AR illumination. Most other components are shared by the OR and AR imaging. The lateral resolution can be seamlessly switched between 2.2 μm and 40 μm as the maximum imaging depth is switched between 1.3 mm and 3.0 mm. The system enables automatically co-registered higher-resolution OR and deeper AR photoacoustic imaging.
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