Paraprobiotics in Non-Surgical Periodontal Therapy: Clinical and Microbiological Aspects in a 6-Month Follow-Up Domiciliary Protocol for Oral Hygiene.
Paraprobiotics in Non-Surgical Periodontal Therapy: Clinical and Microbiological Aspects in a 6-Month Follow-Up Domiciliary Protocol for Oral Hygiene.
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DOI：
10.3390/microorganisms10020337
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发表时间：
2022-02-01
期刊：
影响因子：
4.5
通讯作者：
Scribante A
中科院分区：
文献类型：
--
作者：
Butera A;Gallo S;Pascadopoli M;Maiorani C;Milone A;Alovisi M;Scribante A
牙周病代表牙齿支持组织的渐进性破坏。近年来，副益生菌被认为是非手术洁治和根面刨(SRP)的一种辅助疗法。这项研究的目的是评估两种新的副益生菌制剂，分别是牙膏和漱口水，对家庭卫生的效果。40例患者随机分为两组：1组(SRP+0.2%洗必泰强化治疗)(对照组)和2组(SRP+Biorepair Peribioma牙膏+Biorepaign Mousse含漱液)(试验组)。在基线(T0)、3个月和6个月后(T1-T2)，牙周临床(探诊时出血、探槽深度、临床附着丧失、出血评分、沟出血指数、菌斑指数、近侧菌斑指数、粘附性牙龈、牙龈萎缩和病理部位)和微生物学参数(病原菌、腐生细菌、扩大的红色复合体、红色复合体、橙色复合体，以及聚集性放线菌、牙龈假单胞菌、金黄色葡萄球菌、齿状密螺旋体、中间普沃特氏菌和核梭杆菌)。实验产品的使用导致所评估的大多数临床指标显著降低，与被视为对照的常规洗必泰相比，这在很大程度上发生了。此外，使用6个月后，上述产品显著降低了病原菌的百分比和与牙周病关系更密切的红色复合体的细菌数量。因此，在这项研究中测试的基于副益生菌的产品似乎代表了对SRP的有效支持，在临床指标和特定的牙周病原体上都有好处。
Periodontal disease represents a progressive destruction of tooth-supporting tissues. Recently, paraprobiotics are regarded as an adjunctive therapy to the non-surgical Scaling-and-Root-Planing (SRP). The aim of this study is to evaluate the efficacy of two new formulations of paraprobiotics, a toothpaste and a mouthwash, respectively, for the domiciliary hygiene. A total of 40 patients were randomly assigned to the following domiciliary treatments: Group 1 (SRP + Curasept Intensive Treatment 0.2% chlorhexidine) (control) and Group 2 (SRP + Biorepair Peribioma toothpaste + Biorepair Peribioma Mousse mouthwash) (trial). At baseline (T0) and after 3 and 6 months (T1–T2), periodontal clinical (Bleeding on Probing, Probing Pocket Depth, Clinical Attachment Loss, Bleeding Score, Sulcus Bleeding Index, Plaque Index, Approximal Plaque Index, Adherent Gingiva, Gingival Recession, and Pathological Sites) and microbiological parameters (Pathological Bacteria, Saprophytic Bacteria, Enlarged Red Complex, Red Complex, Orange Complex, and counts of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythensys, Treponema denticola, Prevotella intermedia, and Fusobacterium nucleatum). The use of the experimental products resulted in a significant reduction of most of the clinical indices assessed, which occurred at a major degree with respect to the conventional chlorhexidine considered as control. Additionally, after 6 months of use, the abovementioned products significantly decreased the percentage of pathological bacteria and the counts of those bacteria constituting the “Red Complex”, more related to the periodontal disease. Accordingly, the paraprobiotics-based products tested in this study seem to represent a valid support to SRP with a benefit on both clinical indices and on specific periodontopathogens.
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DOI：
10.3390/ijerph17207651
发表时间：
2020-10-20
影响因子：
--
作者：
Dubar M;Clerc-Urmès I;Baumann C;Clément C;Alauzet C;Bisson C
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作者：
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Nasri W
影响因子：
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作者：
Ince, Gizem;Gursoy, Hare;Yilmaz, Selcuk
通讯作者：
Yilmaz, Selcuk
DOI：
10.1007/s10096-015-2555-y
发表时间：
2016-03-01
影响因子：
4.5
作者：
Martelli, F. S.;Fanti, E.;Medico, E.
通讯作者：
Medico, E.
影响因子：
4.5
作者：
Mocanu RC;Martu MA;Luchian I;Sufaru IG;Maftei GA;Ioanid N;Martu S;Tatarciuc M
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Tatarciuc M