Quantification of aortic stiffness using MR elastography and its comparison to MRI-based pulse wave velocity.
Quantification of aortic stiffness using MR elastography and its comparison to MRI-based pulse wave velocity.
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DOI：
10.1002/jmri.24506
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发表时间：
2015-01
影响因子：
4.4
通讯作者：
Kolipaka, Arunark
中科院分区：
文献类型：
--
作者：
Damughatla, Anirudh R.;Raterman, Brian;Sharkey-Toppen, Travis;Jin, Ning;Simonetti, Orlando P.;White, Richard D.;Kolipaka, Arunark
目的：研究磁共振弹性成像(μ)和基于磁共振的脉搏波速度(PWV)剪切刚度(μPWV)在不同年龄健康志愿者腹主动脉硬度中的相关性，以及μMRE和μPWV之间的相关性。对21名年龄在18~65岁的健康志愿者进行了在体主动脉MRE和MRI检查，获得腹主动脉长轴方向的血流频谱和血流速度数据。分析MRE波图以获得平均刚度，并分析相衬图像以获得PWV测量值，并从Moens-Korteweg方程间接估计刚性值。μ的MRE和μ的PWV值均随年龄增长而增加，与R2分别为0.81和0.67，呈线性相关。青年健康志愿者与老年健康志愿者的平均≤、μ均值、μ均值均有显著差异(p<0.001)。此外，在初始志愿者池中，μ的MRE与μ的PWV之间存在较差的线性相关(R2=0.43)。本研究的结果表明，μ的MRE和μ的PWV与腹主动脉的正常老化呈线性相关。青年健康志愿者与老年健康志愿者的平均μ、μ、MRE、PWV差异均有统计学意义。
To determine the correlation in abdominal aortic stiffness obtained using magnetic resonance elastography (MRE) (μMRE) and MRI-based pulse wave velocity (PWV) shear stiffness (μPWV) estimates in normal volunteers of varying age; and also to determine the correlation between μMRE and μPWV. In-vivo aortic MRE and MRI were performed on 21 healthy volunteers with ages ranging from 18 to 65 years to obtain wave and velocity data along the long-axis of the abdominal aorta. The MRE wave images were analyzed to obtain mean stiffness, and the phase contrast images were analyzed to obtain PWV measurements and indirectly estimate stiffness values from Moens-Korteweg equation. Both μMRE and μPWV measurements increased with age, demonstrating linear correlations with R2 values of 0.81 and 0.67, respectively. Significant difference (p≤0.001) in mean μMRE and μPWV between young and old healthy volunteers was also observed. Furthermore, a poor linear correlation of R2 value of 0.43 was determined between μMRE and μPWV in initial pool of volunteers. The results of this study indicate linear correlations between μMRE and μPWV with normal aging of the abdominal aorta. Significant differences in mean μMRE and μPWV between young and old healthy volunteers were observed.
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影响因子：
8.3
作者：
Rezai, Mohammad-Reza;Wallace, A. Michael;Cruickshank, J. Kennedy
通讯作者：
Cruickshank, J. Kennedy
影响因子：
2.9
作者：
Sack, Ingolf;Beierbach, Bernd;Braun, Juergen
通讯作者：
Braun, Juergen
影响因子：
39.3
作者：
Reference Values for Arterial Stiffness' Collaboration
通讯作者：
Reference Values for Arterial Stiffness' Collaboration
影响因子：
56.9
作者：
MUTHUPILLAI, R;LOMAS, DJ;EHMAN, RL
通讯作者：
EHMAN, RL
影响因子：
4.4
作者：
Mihai, Georgeta;Chung, Yiu-Cho;Rajagopalan, Sanjay
通讯作者：
Rajagopalan, Sanjay