Fungal cytochrome P450 database.

Fungal cytochrome P450 database.
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DOI:
10.1186/1471-2164-9-402
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发表时间:
2008-08-28
期刊:
影响因子:
4.4
通讯作者:
Lee YH
Lee YH
中科院分区:
生物学2区
文献类型:
--
作者:
Park J;Lee S;Choi J;Ahn K;Park B;Park J;Kang S;Lee YH

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细胞色素P450酶在真菌生物学和生态学中起着重要作用。为了支持真菌细胞色素P450酶的作用和进化的研究,基于快速积累的基因组序列从不同的真菌物种,一个高效的生物信息学平台,专门为这个超级家族的蛋白质是非常必要的。真菌细胞色素P450数据库(FCPD)存档了66种真菌和4种卵菌(共4,538种)基因组中编码P450的基因,并支持对其序列,染色体分布模式,进化历史和关系的分析。根据InterPro术语将存档的P450分为16类,并使用部落MCL聚类为141组。P450蛋白在总蛋白质组中所占比例和类的分布具有一定的类群特异性。FCPD将通过网络促进P450在多个分类单元水平上的系统识别和多方面分析。所有的数据和功能都可以在网站上找到。
Cytochrome P450 enzymes play critical roles in fungal biology and ecology. To support studies on the roles and evolution of cytochrome P450 enzymes in fungi based on rapidly accumulating genome sequences from diverse fungal species, an efficient bioinformatics platform specialized for this super family of proteins is highly desirable. The Fungal Cytochrome P450 Database (FCPD) archives genes encoding P450s in the genomes of 66 fungal and 4 oomycete species (4,538 in total) and supports analyses of their sequences, chromosomal distribution pattern, and evolutionary histories and relationships. The archived P450s were classified into 16 classes based on InterPro terms and clustered into 141 groups using tribe-MCL. The proportion of P450s in the total proteome and class distribution in individual species exhibited certain taxon-specific characteristics. The FCPD will facilitate systematic identification and multifaceted analyses of P450s at multiple taxon levels via the web. All data and functions are available at the web site .
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