Differential executive functioning performance by phase of bipolar disorder.
Differential executive functioning performance by phase of bipolar disorder.
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DOI：
10.1111/j.1399-5618.2012.01032.x
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发表时间：
2012-08
影响因子：
5.4
通讯作者：
McInnis MG
中科院分区：
文献类型：
--
作者：
Ryan KA;Vederman AC;McFadden EM;Weldon AL;Kamali M;Langenecker SA;McInnis MG
本研究在横断面设计中使用因素衍生的认知评分来检验疾病阶段对执行功能表现的影响。对健康对照（HC）受试者（n = 57）、心境正常（E-BD） （n = 117）、抑郁（D-BD） （n = 73）和轻躁/混合性（HM/M-BD）双相情感障碍（BD）患者（n = 26）进行执行功能测试（威斯康星卡片分类测试、轨迹制作测试A和B部分、语言流畅性、参数化Go/No-Go、Stroop和数字符号），包括概念推理和集移（CRSS）、干扰分辨率处理速度（PSIR）、语言流畅性和加工速度（VFPS）和抑制控制（IC）因子得分。四项执行功能因素中的两项在不同疾病阶段的组间存在显著差异。HM/M组在IC中的表现明显差于其他BD组和HC组，VFPS因子对BD的活动期敏感，HM/M-BD组和D-BD组较HC组差。延伸我们之前的工作，无论疾病的哪个阶段，BD的PSIR因子和现在的CRSS因子都明显比HC差。即使在考虑并排除临床特征、疾病特征、药物和人口统计学的影响后，疾病阶段在执行功能因素方面具有不同的认知概况。将执行功能任务整合为可靠的因素评分，为测量和定义双相障碍各阶段的认知缺陷，以及测量双相障碍的中间表型提供了独特的信息，并可能有助于跟踪和明确治疗重点。
This study examined the influence of illness phase on executive functioning performance using factor-derived cognitive scores in a cross-sectional design. Healthy control (HC) subjects (n = 57), and euthymic (E-BD) (n = 117), depressed (D-BD) (n = 73), and hypomanic/mixed (HM/M-BD) (n = 26) patients with bipolar disorder (BD) were evaluated using executive functioning measures (Wisconsin Card Sorting Test, Trail Making Test–Parts A and B, Verbal Fluency, Parametric Go/No-Go, Stroop, and Digit Symbol) comprising Conceptual Reasoning and Set-Shifting (CRSS), Processing Speed with Interference Resolution (PSIR), Verbal Fluency and Processing Speed (VFPS), and Inhibitory Control (IC) factor scores. Two of the four executive functioning factors were significantly different between groups based upon phase of illness. The HM/M group was significantly worse than both of the other BD groups and the HC group in IC. The VFPS factor was sensitive to the active phase of BD, with the HM/M-BD and D-BD groups worse than HC. Extending our prior work, the PSIR factor, and now the CRSS factor were significantly worse in BD relative to HC, irrespective of phase of illness. Phase of illness had differential cognitive profiles in executive functioning factors, even after considering and excluding the impact of clinical features, illness characteristics, medications, and demographics. Consolidating executive functioning tasks into reliable factor scores provides unique information to measure and define cognitive deficiencies throughout phases of BD, and to measure intermediate phenotypes in BD, and may aid in tracking and clarifying treatment focus.
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影响因子：
4.5
作者：
McGrath, J;Scheldt, S;Clair, A
通讯作者：
Clair, A
影响因子：
10.6
作者：
Clark, L;Kempton, MJ;Goodwin, GM
通讯作者：
Goodwin, GM
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作者：
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Salamero, M
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2.4
作者：
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通讯作者：
Purdie, R
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2.4
作者：
Kurtz, Matthew M.;Gerraty, Raphael T.
通讯作者：
Gerraty, Raphael T.