The Differential Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Cardiometabolic Risk Factors: A Systematic Review.
The Differential Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Cardiometabolic Risk Factors: A Systematic Review.
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DOI：
10.3390/ijms19020532
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发表时间：
2018-02-09
影响因子：
5.6
通讯作者：
Calder PC
中科院分区：
文献类型：
--
作者：
Innes JK;Calder PC
大量证据支持长链欧米茄-3多不饱和脂肪酸（PUFA）、二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）的心脏保护作用。人们越来越关注EPA和DHA在调节心脏代谢危险因素中的独立作用。本系统综述旨在评估EPA和DHA对这些危险因素的不同影响的最新证据。截至2017年5月进行了系统性文献综述。如果符合严格的合格标准，包括EPA或DHA > 2 g/天和纯度≥ 90%，则纳入随机对照试验。纳入了18篇识别出的文章，对应于6项涉及527名受试者的独特研究。EPA和DHA都能降低甘油三酯的浓度，其中DHA具有更大的降低甘油三酯的作用。虽然总胆固醇水平在很大程度上不受EPA和DHA的影响，但DHA增加了高密度脂蛋白（HDL）胆固醇浓度，特别是HDL 2，并增加了低密度脂蛋白（LDL）胆固醇浓度和LDL颗粒大小。EPA和DHA都能抑制血小板活性，而DHA能改善血管功能，降低心率和血压，其程度比EPA更大。EPA和DHA对炎症标志物和血液病控制的影响尚不确定;然而，两者都降低了氧化应激。因此，EPA和DHA似乎对心脏代谢危险因素有不同的影响，但这些需要通过更大规模的临床研究来证实。
A large body of evidence supports the cardioprotective effects of the long-chain omega-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). There is increasing interest in the independent effects of EPA and DHA in the modulation of cardiometabolic risk factors. This systematic review aims to appraise the latest available evidence of the differential effects of EPA and DHA on such risk factors. A systematic literature review was conducted up to May 2017. Randomised controlled trials were included if they met strict eligibility criteria, including EPA or DHA > 2 g/day and purity ≥ 90%. Eighteen identified articles were included, corresponding to six unique studies involving 527 participants. Both EPA and DHA lowered triglyceride concentration, with DHA having a greater triglyceride-lowering effect. Whilst total cholesterol levels were largely unchanged by EPA and DHA, DHA increased high-density lipoprotein (HDL) cholesterol concentration, particularly HDL2, and increased low-density lipoprotein (LDL) cholesterol concentration and LDL particle size. Both EPA and DHA inhibited platelet activity, whilst DHA improved vascular function and lowered heart rate and blood pressure to a greater extent than EPA. The effects of EPA and DHA on inflammatory markers and glycaemic control were inconclusive; however both lowered oxidative stress. Thus, EPA and DHA appear to have differential effects on cardiometabolic risk factors, but these need to be confirmed by larger clinical studies.
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影响因子：
7.1
作者：
Allaire, Janie;Couture, Patrick;Lamarche, Benoit
通讯作者：
Lamarche, Benoit
DOI：
10.1016/j.plefa.2017.03.008
发表时间：
2017-05-01
影响因子：
3
作者：
Allaire, Janie;Harris, William S.;Lamarche, Benoit
通讯作者：
Lamarche, Benoit
影响因子：
7.1
作者：
Grimsgaard, S;Bonaa, KH;Myhre, ESP
通讯作者：
Myhre, ESP
DOI：
10.1016/0952-3278(92)90043-i
发表时间：
1992-08-01
影响因子：
3
作者：
DUPLOOY, WJ;VENTER, CP;SMITH, KA
通讯作者：
SMITH, KA
影响因子：
7
作者：
Calder, P. C.
通讯作者：
Calder, P. C.