Roux-en-Y gastric bypass increases intravenous ethanol self-administration in dietary obese rats.
Roux-en-Y gastric bypass increases intravenous ethanol self-administration in dietary obese rats.
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DOI：
10.1371/journal.pone.0083741
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Hajnal A
中科院分区：
文献类型：
--
作者：
Polston JE;Pritchett CE;Tomasko JM;Rogers AM;Leggio L;Thanos PK;Volkow ND;Hajnal A
Roux-en-Y胃旁路手术（RYGB）是治疗重度肥胖的有效方法。然而，临床研究报告了RYGB后增加酒精使用的敏感性，临床前研究表明RYGB后肥胖大鼠的酒精摄入量增加。这可能反映了酒精在大脑中的奖励效应的直接增强，或者是由于RGYB后酒精吸收增加而产生的间接效应。为了排除酒精吸收的变化对其奖励作用的影响，我们在这里评估了RYGB对静脉注射（IV）乙醇（1%）的影响。为此，在RYGB或假手术（SHAM）后2个月，使用固定和渐进比例强化方案对高脂肪（60%千卡来自脂肪）饮食诱导的肥胖雄性Sprague道利大鼠进行测试，以评估RGYB是否改变IV乙醇的强化效果。与假手术组相比，RYGB大鼠在固定比例时间表期间对获得IV乙醇做出了更积极的喷射反应，并且在渐进比例时间表期间实现了更高的断点。虽然还需要更多的研究，但我们的研究结果提供了初步证据，表明RYGB增加了酒精的奖励效应，而不依赖于其对酒精吸收的影响。
Roux-en-Y gastric bypass surgery (RYGB) is an effective treatment for severe obesity. Clinical studies however have reported susceptibility to increased alcohol use after RYGB, and preclinical studies have shown increased alcohol intake in obese rats after RYGB. This could reflect a direct enhancement of alcohol’s rewarding effects in the brain or an indirect effect due to increased alcohol absorption after RGYB. To rule out the contribution that changes in alcohol absorption have on its rewarding effects, here we assessed the effects of RYGB on intravenously (IV) administered ethanol (1%). For this purpose, high fat (60% kcal from fat) diet-induced obese male Sprague Dawley rats were tested ∼2 months after RYGB or sham surgery (SHAM) using both fixed and progressive ratio schedules of reinforcement to evaluate if RGYB modified the reinforcing effects of IV ethanol. Compared to SHAM, RYGB rats made significantly more active spout responses to earn IV ethanol during the fixed ratio schedule, and achieved higher breakpoints during the progressive ratio schedule. Although additional studies are needed, our results provide preliminary evidence that RYGB increases the rewarding effects of alcohol independent of its effects on alcohol absorption.
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DOI：
10.1152/ajpendo.00582.2003
发表时间：
2004-08-01
影响因子：
5.1
作者：
Cummings, DE;Frayo, RS;Chapelot, D
通讯作者：
Chapelot, D
影响因子：
2.9
作者：
Davis, Jon F.;Tracy, Andrea L.;Schurdak, Jennifer D.;Magrisso, Irwin J.;Grayson, Bernadette E.;Seeley, Randy J.;Benoit, Stephen C.
通讯作者：
Benoit, Stephen C.
影响因子：
3.1
作者：
Hagedorn, Judith C.;Encarnacion, Betsy;Morton, John M.
通讯作者：
Morton, John M.
影响因子：
10.6
作者：
Davis, Jon F.;Schurdak, Jennifer D.;Benoit, Stephen C.
通讯作者：
Benoit, Stephen C.
DOI：
10.1177/0148607110381403
发表时间：
2011-03
期刊：
JPEN. Journal of parenteral and enteral nutrition
影响因子：
--
作者：
Beckman LM;Beckman TR;Sibley SD;Thomas W;Ikramuddin S;Kellogg TA;Ghatei MA;Bloom SR;le Roux CW;Earthman CP
通讯作者：
Earthman CP