Post-exposure environment modulates long-term developmental ethanol effects on behavior, neuroanatomy, and cortical oscillations.
Post-exposure environment modulates long-term developmental ethanol effects on behavior, neuroanatomy, and cortical oscillations.
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DOI：
10.1016/j.brainres.2020.147128
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发表时间：
2020-12-01
期刊：
影响因子：
2.9
通讯作者：
Wilson DA
中科院分区：
文献类型：
--
作者：
Apuzzo J;Saito M;Wilson DA
发育过程中接触酒精会对人体产生广泛的解剖学、细胞学、生理学和行为学方面的影响，这些影响可能会持续终生。在人类中，这种影响被称为胎儿酒精谱系障碍，在西方文化中非常普遍。然而，发育期酒精暴露的影响的最终表达可能会受到暴露后经验的影响。在这里，我们研究了C57BL/6BY小鼠发育期过度酒精暴露(出生后第7天)对一组相互关联的长期结果的特定队列的影响，这些结果包括上下文记忆、海马小白蛋白表达神经元密度、与睡眠-觉醒周期相关的额叶皮质振荡(包括增量振荡幅度和睡眠纺锤密度)以及家庭笼子行为。当对在标准住房中长大的成年人进行评估时，与生理盐水对照组相比，所有这些因素都在早期接触酒精的情况下发生了变化，但家庭笼子活动除外。然而，从断奶到出生后第90天，暴露在丰富的环境中和锻炼可以逆转酒精诱导的大部分损害，包括记忆、CA1但不能逆转齿状回PV+细胞密度、三角洲振荡和睡眠纺锤，以及增强生理盐水但不是乙醇处理的小鼠的家庭笼子行为活动。结果从不同发育酒精结果的相互依赖和暴露后经验调节这些结果的潜在机制的角度进行了讨论。
Developmental exposure to ethanol has a wide range of anatomical, cellular, physiological and behavioral impacts that can last throughout life. In humans, this cluster of effects is termed fetal alcohol spectrum disorder and is highly prevalent in western cultures. The ultimate expression of the effects of developmental ethanol exposure however can be influenced by post-exposure experience. Here we examined the effects of developmental binge exposure to ethanol (postnatal day 7) in C57BL/6By mice on a specific cohort of inter-related long-term outcomes including contextual memory, hippocampal parvalbumin-expressing neuron density, frontal cortex oscillations related to sleep-wake cycling including delta oscillation amplitude and sleep spindle density, and home-cage behavioral activity. When assessed in adults that were raised in standard housing, all of these factors were altered by early ethanol exposure compared to saline controls except home-cage activity. However, exposure to an enriched environment and exercise from weaning to postnatal day 90 reversed most of these ethanol-induced impairments including memory, CA1 but not dentate gyrus PV+ cell density, delta oscillations and sleep spindles, and enhanced home-cage behavioral activity in Saline- but not EtOH-treated mice. The results are discussed in terms of the inter-dependence of diverse developmental ethanol outcomes and potential mechanisms of post-exposure experiences to regulate those outcomes.
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