Magnesium intake is inversely associated with coronary artery calcification: the Framingham Heart Study.
Magnesium intake is inversely associated with coronary artery calcification: the Framingham Heart Study.
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DOI：
10.1016/j.jcmg.2013.10.006
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发表时间：
2014-01
期刊：
影响因子：
--
通讯作者：
McKeown NM
中科院分区：
文献类型：
--
作者：
Hruby A;O'Donnell CJ;Jacques PF;Meigs JB;Hoffmann U;McKeown NM
这项研究的目的是检查镁摄入量是否与冠状动脉钙化(CAC)和腹主动脉钙化(AAC)相关。动物和细胞研究表明，镁可以防止心血管疾病背后的动脉粥样硬化斑块内的钙化。人们对镁摄入量与动脉粥样硬化性钙化之间的关系知之甚少。我们检验了弗雷明翰心脏研究参与者(n=2,695；年龄：53±11岁)的自我报告的总(饮食和补充)镁摄入量与CAC和AAC的食物频率问卷估计的横截面关系，这些参与者没有心血管疾病，采用多变量调整的Tobit回归。CAC和AAC采用改良的Agatston评分(AS)进行量化。模型根据年龄、性别、体重指数、吸烟状态、收缩压、空腹胰岛素、总与高密度脂蛋白胆固醇的比率、激素替代疗法的使用(仅限女性)、更年期状态(仅限女性)、高脂血症、高血压、心血管疾病预防或糖尿病的治疗以及自我报告的钙、维生素D和K、饱和脂肪、纤维、酒精和能量的摄入量进行了调整。二次分析包括以CAC和AAC结果为切入点的Logistic回归分析(AS>；0和年龄和性别的≥第90百分位数)，以及性别分层分析。在完全调整的模型中，自我报告的总镁摄入量每天增加50毫克与CAC22%(p<；0.001)和AAC降低12%(p=0.07)相关。与这些观察结果一致的是，与镁摄入量最低的人相比，镁摄入量最高的人患CAC的几率低58%(p趋势：0.001)，患AAC的几率低34%(p趋势：0.01)。在女性中观察到了比男性更强的反向关联。在没有心血管疾病的社区居民中，自我报告的镁摄入量与动脉钙化呈负相关，这可能在镁在中风和致命冠心病中的保护性关联中发挥作用。
The aim of this study was to examine whether magnesium intake is associated with coronary artery calcification (CAC) and abdominal aortic calcification (AAC). Animal and cell studies suggest that magnesium may prevent calcification within atherosclerotic plaques underlying cardiovascular disease. Little is known about the association of magnesium intake and atherosclerotic calcification in humans. We examined cross-sectional associations of self-reported total (dietary and supplemental) magnesium intake estimated by food frequency questionnaire with CAC and AAC in participants of the Framingham Heart Study who were free of cardiovascular disease and underwent Multi-Detector Computed Tomography (MDCT) of the heart and abdomen (n = 2,695; age: 53 ± 11 years), using multivariate-adjusted Tobit regression. CAC and AAC were quantified using modified Agatston scores (AS). Models were adjusted for age, sex, body mass index, smoking status, systolic blood pressure, fasting insulin, total-to-high-density lipoprotein cholesterol ratio, use of hormone replacement therapy (women only), menopausal status (women only), treatment for hyperlipidemia, hypertension, cardiovascular disease prevention, or diabetes, as well as self-reported intake of calcium, vitamins D and K, saturated fat, fiber, alcohol, and energy. Secondary analyses included logistic regressions of CAC and AAC outcomes as cut-points (AS >0 and AS ≥90th percentile for age and sex), as well as sex-stratified analyses. In fully adjusted models, a 50-mg/day increment in self-reported total magnesium intake was associated with 22% lower CAC (p < 0.001) and 12% lower AAC (p = 0.07). Consistent with these observations, the odds of having any CAC were 58% lower (p trend: <0.001) and any AAC were 34% lower (p trend: 0.01), in those with the highest compared to those with the lowest magnesium intake. Stronger inverse associations were observed in women than in men. In community-dwelling participants free of cardiovascular disease, self-reported magnesium intake was inversely associated with arterial calcification, which may play a contributing role in magnesium's protective associations in stroke and fatal coronary heart disease.
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影响因子：
3.2
作者：
Leidi, Marzia;Dellera, Federica;Maier, Jeanette A. M.
通讯作者：
Maier, Jeanette A. M.
影响因子：
19.6
作者：
Fox, CS;Larson, MG;O'Donnell, CJ
通讯作者：
O'Donnell, CJ
影响因子：
4.8
作者：
Alexopoulos, D;Toulgaridis, T;Vagenakis, AG
通讯作者：
Vagenakis, AG
影响因子：
2.8
作者：
Chuang, Michael L.;Massaro, Joseph M.;O'Donnell, Christopher J.
通讯作者：
O'Donnell, Christopher J.
DOI：
10.1016/j.nutres.2009.05.001
发表时间：
2009-05
期刊：
Nutrition research (New York, N.Y.)
影响因子：
--
作者：
King JL;Miller RJ;Blue JP Jr;O'Brien WD Jr;Erdman JW Jr
通讯作者：
Erdman JW Jr