Optical coherence elastography assessment of corneal viscoelasticity with a modified Rayleigh-Lamb wave model.
Optical coherence elastography assessment of corneal viscoelasticity with a modified Rayleigh-Lamb wave model.
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DOI：
10.1016/j.jmbbm.2016.11.004
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发表时间：
2017-02
影响因子：
3.9
通讯作者：
Larin KV
中科院分区：
文献类型：
--
作者：
Han Z;Li J;Singh M;Wu C;Liu CH;Raghunathan R;Aglyamov SR;Vantipalli S;Twa MD;Larin KV
角膜的生物力学特性在形成视觉中起着关键作用。圆锥角膜等疾病可使角膜结构退化，导致视力的病理性丧失。UV-A/核黄素角膜胶原交联（CXL）是临床上可用于修复角膜并恢复其健康形状和功能的治疗方法。然而，目前的CXL技术没有考虑到角膜的预先存在的生物力学特性，也没有考虑到CXL治疗本身的效果。除了固有的角膜结构之外，眼内压（IOP）也可以显著地影响角膜的测量的生物力学性质。在这项工作中，我们提出了一个修改后的Rayleigh-Lamb频率方程模型的细节和发展量化角膜生物力学性能。在与有限元建模比较后，基于非接触式光学相干弹性成像测量，利用该模型来量化CXL前后整个眼球结构中原位猪角膜的粘弹性。此外，在各种IOP下定量未处理和CXL处理的眼睛的粘弹性。结果表明，CXL后角膜硬度增加，角膜硬度与IOP呈近似线性关系。这些结果表明，修改后的Rayleigh-Lamb波模型可以提供准确的评估角膜粘弹性，这可以用于定制的CXL治疗。
The biomechanical properties of the cornea play a critical role in forming vision. Diseases such as keratoconus can structurally degenerate the cornea causing a pathological loss in visual acuity. UV-A/riboflavin corneal collagen crosslinking (CXL) is a clinically available treatment to stiffen the cornea and restore its healthy shape and function. However, current CXL techniques do not account for pre-existing biomechanical properties of the cornea nor the effects of the CXL treatment itself. In addition to the inherent corneal structure, the intraocular pressure (IOP) can also dramatically affect the measured biomechanical properties of the cornea. In this work, we present the details and development of a modified Rayleigh-Lamb frequency equation model for quantifying corneal biomechanical properties. After comparison with finite element modeling, the model was utilized to quantify the viscoelasticity of in situ porcine corneas in the whole eye-globe configuration before and after CXL based on noncontact optical coherence elastography measurements. Moreover, the viscoelasticity of the untreated and CXL-treated eyes was quantified at various IOPs. The results showed that the stiffness of the cornea increased after CXL and that corneal stiffness is close to linear as a function of IOP. These results show that the modified Rayleigh-Lamb wave model can provide an accurate assessment of corneal viscoelasticity, which could be used for customized CXL therapies.
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影响因子：
3.4
作者：
Dias J;Diakonis VF;Lorenzo M;Gonzalez F;Porras K;Douglas S;Avila M;Yoo SH;Ziebarth NM
通讯作者：
Ziebarth NM
影响因子：
2.8
作者：
Ford, Matthew R.;Roy, Abhijit Sinha;Dupps, William J., Jr.
通讯作者：
Dupps, William J., Jr.
DOI：
10.1007/s00417-011-1897-0
发表时间：
2012-04-01
影响因子：
2.7
作者：
Gkika, Maria;Labiris, Georgios;Kozobolis, Vassilios
通讯作者：
Kozobolis, Vassilios
影响因子：
3.4
作者：
Elsheikh, Ahmed;Alhasso, Daad;Rama, Paolo
通讯作者：
Rama, Paolo
影响因子：
2.8
作者：
Goldich, Yakov;Barkana, Yaniv;Zadok, David
通讯作者：
Zadok, David