Interaction effects of ultrafine carbon black with iron and nickel on heart rate variability in spontaneously hypertensive rats.
Interaction effects of ultrafine carbon black with iron and nickel on heart rate variability in spontaneously hypertensive rats.
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超铁碳与铁和镍的相互作用对自发性高血压大鼠心率变异性的相互作用。
DOI：
10.1289/ehp.9821
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发表时间：
2007-07
影响因子：
10.4
通讯作者：
Cheng, Tsun-Jen
中科院分区：
文献类型：
--
作者：
Chang, Chuen-Chau;Hwang, Jing-Shiang;Chan, Chang-Chuan;Cheng, Tsun-Jen
关键词：
据报道，颗粒物（PM）与心率变异性（HRV）的改变有关;然而，结果并不一致。我们建议，PM的不同成分造成的差异。在这项研究中，我们的目标是确定不同类型的暴露是否会导致不同的HRV效应，并验证共同暴露成分之间的相互作用。超细炭黑（ufCB; 14 nm;分别向自发性高血压大鼠气管内滴注硫酸铁[Fe 2（SO 4）3; 105 μg和210 μg]、硫酸镍（NiSO 4; 263 μg和526 μg）以及高剂量ufCB和低剂量Fe 2（SO 4）3或NiSO 4的组合。在基线时收集大鼠72小时的无线电遥测数据，并在接下来的一周收集72小时的无线电遥测数据，以确定对暴露的反应。使用自身对照实验设计分析暴露对5 min平均正常-正常间期（ANN）、正常-正常间期自然对数转换标准差（LnSDNN）和相邻正常-正常间期连续差异的均方根（LnRMSSD）的影响。高剂量和低剂量ufCB均在30小时左右略微降低ANN，同时LnSDNN增加。LnRMSSD在初始小幅增加后恢复至基线水平。我们观察到小剂量的铁和镍滴注后的影响，而双相变化后，高剂量滴注。ufCB和铁或镍的组合暴露导致HRV趋势不同于从个体成分效应估计的值。PM中的成分可以引起不同的心脏调节反应，并且单一成分可以在不同的阶段引起不同的反应。同时暴露于ufCB和Fe或Ni可能会对心脏调节作用产生相互作用。此外，PM的影响可能是通过PM的不同成分之间的复杂相互作用来介导的。
Particulate matter (PM) has been reported to be associated with alterations in heart rate variability (HRV); however, the results are inconsistent. We propose that different components of PM cause the discrepancy. In this study, our goal was to determine whether different types of exposure would cause different HRV effects, and to verify the interactions between co-exposing components. Ultrafine carbon black (ufCB; 14 nm; 415 μg and 830 μg), ferric sulfate [Fe2(SO4)3; 105 μg and 210 μg], nickel sulfate (NiSO4; 263 μg and 526 μg), and a combination of high-dose ufCB and low-dose Fe2(SO4)3 or NiSO4 were intratracheally instilled into spontaneously hypertensive rats. Radiotelemetry data were collected in rats for 72 hr at baseline and for 72 hr the following week to determine the response to exposure. Effects of exposure on 5-min average of normal-to-normal intervals (ANN), natural logarithm-transformed standard deviation of the normal-to-normal intervals (LnSDNN), and root mean square of successive differences of adjacent normal-to-normal intervals (LnRMSSD) were analyzed using self-control experimental designs. Both high- and low-dose ufCB decreased ANN marginally around hour 30, with concurrent increases of LnSDNN. LnRMSSD returned to baseline levels after small initial increases. We observed minor effects after low-dose Fe and Ni instillation, whereas biphasic changes were noted after high-dose instillations. Combined exposures of ufCB and either Fe or Ni resulted in HRV trends different from values estimated from individual-component effects. Components in PM may induce different cardioregulatory responses, and a single component may induce different responses during different phases. Concurrent exposure to ufCB and Fe or Ni might introduce interactions on cardioregulatory effects. Also, the effect of PM may be mediated through complex interaction between different components of PM.
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影响因子：
10.4
作者：
Dockery, DW
通讯作者：
Dockery, DW
DOI：
10.1164/rccm.200402-248oc
发表时间：
2005-02-15
影响因子：
24.7
作者：
Arimoto, T;Kadiiska, MB;Mason, RP
通讯作者：
Mason, RP
影响因子：
3.8
作者：
Driscoll, KE;Costa, DL;Schlesinger, RB
通讯作者：
Schlesinger, RB
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影响因子：
10
作者：
Hetland RB;Cassee FR;Låg M;Refsnes M;Dybing E;Schwarze PE
通讯作者：
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人类受试者的个人暴露于亚微米颗粒和心率变异性。
影响因子：
10.4
作者：
Chan, Chang-Chuan;Chuang, Kai-Jen;Shiao, Guang-Ming;Lin, Lian-Yu
通讯作者：
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