Reciprocal deterioration of visual and auditory hallucinations in schizophrenia presents V-shaped cognition impairment and widespread reduction in brain gray matter-A pilot study
Reciprocal deterioration of visual and auditory hallucinations in schizophrenia presents V-shaped cognition impairment and widespread reduction in brain gray matter-A pilot study
复制标题
精神分裂症中幻视和幻听的相互恶化呈现V形认知障碍和大脑灰质的广泛减少——一项初步研究
DOI：
10.1016/j.jocn.2020.07.054
复制
发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
Chuanjun Zhuo
中科院分区：
文献类型：
--
作者：
Chuanjun Zhuo
精神分裂症患者经常会出现幻视和幻听，然而，与精神分裂症患者合并VH和AH相关的脑畸变仍缺乏文献记载。对首次发病的未治疗的精神分裂症患者（FUSCH）的大脑和认知功能的变化进行了评估。入组了157例接受FUSCH（1）伴VH但不伴AH（FUSCHV）和（2）伴AH但不伴VH（FUSCHA）的患者，加上FUSCHVA和健康对照（n = 30）。测量灰质体积（GMV）和MATRICS共识认知测验（MCCB），以分别反映大脑和认知的损害。FUSCHVA患者对MCCB的所有成分的认知障碍最严重，其次是FUSCHV和FUSCHA患者。与健康患者相比，FUSCHVA患者的枕叶、顶叶、额叶和颞叶皮质GMV降低，海马和纹状体GMV增加。与FUSCHV患者相比，FUSCHVA患者枕叶皮质和中央后回的GMV减少，顶叶后叶的GMV增加。与FUSCHA患者相比，FUSCHVV患者的GMV在枕叶皮质和后顶叶降低。总之，幻视和幻听似乎恶化了FUSCHVA患者的视力，并伴有严重的认知障碍。与AH相比，VHS可能伴有严重的脑GMV损害，尤其是在初级视觉皮层和高级感知整合皮层（后顶叶）。
Schizophrenic patients often experience visual hallucinations (VHs) and auditory hallucinations (AHs); however, brain aberrations associated with combined VH and AH in schizophrenic patients remains poorly documented. Changes to the brain and cognition during the first episode of untreated schizophrenic patients (FUSCH) with both VHs and AHs (FUSCHVA) were evaluated. One-hundred and fifty-seven patients were enrolled that had FUSCH (1) with VHs but not AHs (FUSCHV), and (2) with AHs but not VHs (FUSCHA), plus FUSCHVA and healthy controls (n = 30). Gray matter volume (GMV) and MATRICS Consensus Cognitive Battery (MCCB) was measured to reflect impairments to the brain and cognition, respectively. FUSCHVA patients had the severest cognitive impairment for all components of the MCCB, followed by FUSCHV and FUSCHA patients. Compared to healthy patients, FUSCHVA patients had reduced GMV in the occipital, parietal, frontal, and temporal cortex, and increased GMV in the hippocampus and striatum. Compared to FUSCHV patients, FUSCHVA patients had reduced GMV in the occipital cortex and postcentral gyrus, and increased GMV in the posterio-parietal lobe. Compared to patients with FUSCHA, the GMV in patients with FUSCHVV was reduced in the occipital cortex and posterio parietal lobe. In conclusion, visual and auditory hallucinations appear to deteriorate reciprocally in FUSCHVA patients, accompanied with sever cognitive impairments. Compared to AHs, VHs might be accompanied with severe GMV impairment in the brain, especially in the primary visual cortex and higher perception integration cortex (posterio parietal lobe) in patients with FUSCH.
登录
查看更多内容
DOI：
10.4172/2155-6105.1000324
发表时间：
2017-01-01
期刊：
Journal of addiction research & therapy
影响因子：
--
作者：
Kumari, Suneeta;Malik, Mansoor;Sonje, Snezana
通讯作者：
Sonje, Snezana
DOI：
--
发表时间：
--
期刊：
--
影响因子：
--
作者：
Leor Zmigrod;Jane R. Garrison;Joseph Carr;J. S. Simons;J. S. Simons
通讯作者：
Leor Zmigrod;Jane R. Garrison;Joseph Carr;J. S. Simons;J. S. Simons
影响因子：
10.6
作者：
Cadenhead, KS;Serper, Y;Braff, DL
通讯作者：
Braff, DL
DOI：
10.1007/978-3-319-30596-7_4
发表时间：
2016-01-01
期刊：
NEUROPSYCHOPATHOLOGY OF SCHIZOPHRENIA: MOLECULES, BRAIN SYSTEMS, MOTIVATION, AND COGNITION
影响因子：
--
作者：
Silverstein, Steven M.
通讯作者：
Silverstein, Steven M.
影响因子：
10.6
作者：
Hebert, Marc;Gagne, Anne-Marie;Maziade, Michel
通讯作者：
Maziade, Michel