Dopamine Rebound-Excitation Theory: Putting Brakes on PTSD.
Dopamine Rebound-Excitation Theory: Putting Brakes on PTSD.
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DOI：
10.3389/fpsyt.2016.00163
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发表时间：
2016
影响因子：
4.7
通讯作者：
Tsien JZ
中科院分区：
文献类型：
--
作者：
Lee JC;Wang LP;Tsien JZ
人类或动物在其一生中经历创伤性事件并不罕见。然而，大多数人对长期的有害变化有弹性，这些变化会转化为焦虑和抑郁，例如创伤后应激障碍（PTSD）。什么潜在的神经机制解释了压力恢复力的个体差异？恐惧回路的过度活跃，如杏仁核系统，是众所周知的PTSD的主要病理生理基础，就像一个“卡住的加速器”。有趣的是，越来越多的证据表明，多巴胺（DA）-传统上以其在动机，奖励预测和成瘾中的作用而闻名-在调节恐惧学习和焦虑方面也至关重要。然而，多巴胺能（DA能）神经元如何控制应激恢复力尚不清楚，特别是考虑到DA能神经元具有不同的时间动力学的多种亚型。在这里，我们提出了反弹兴奋理论，它假定DA能神经元的反弹兴奋在恐惧的经验终止作为一个重要的“刹车”，通过提供内在的安全信号，以空间和时间控制的方式恐惧处理神经回路。我们讨论了DA能神经元的反弹兴奋可能受到遗传和经验的调节，以及这些生理特性如何被用作脑活动生物标志物来预测和赋予个体对压力和焦虑的恢复力。
It is not uncommon for humans or animals to experience traumatic events in their lifetimes. However, the majority of individuals are resilient to long-term detrimental changes turning into anxiety and depression, such as post-traumatic stress disorder (PTSD). What underlying neural mechanism accounts for individual variability in stress resilience? Hyperactivity in fear circuits, such as the amygdalar system, is well-known to be the major pathophysiological basis for PTSD, much like a “stuck accelerator.” Interestingly, increasing evidence demonstrates that dopamine (DA) – traditionally known for its role in motivation, reward prediction, and addiction – is also crucial in regulating fear learning and anxiety. Yet, how dopaminergic (DAergic) neurons control stress resilience is unclear, especially given that DAergic neurons have multiple subtypes with distinct temporal dynamics. Here, we propose the Rebound-Excitation Theory, which posits that DAergic neurons’ rebound-excitation at the termination of fearful experiences serves as an important “brake” by providing intrinsic safety-signals to fear-processing neural circuits in a spatially and temporally controlled manner. We discuss how DAergic neuron rebound-excitation may be regulated by genetics and experiences, and how such physiological properties may be used as a brain-activity biomarker to predict and confer individual resilience to stress and anxiety.
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神经元型特异性信号，用于腹侧对段区域的奖励和惩罚。
影响因子：
64.8
作者：
Cohen, Jeremiah Y.;Haesler, Sebastian;Vong, Linh;Lowell, Bradford B.;Uchida, Naoshige
通讯作者：
Uchida, Naoshige
影响因子：
10.6
作者：
Christianson, John P.;Jennings, Joshua H.;Ragole, Thomas;Flyer, Johana G. N.;Benison, Alexander M.;Barth, Daniel S.;Watkins, Linda R.;Maier, Steven F.
通讯作者：
Maier, Steven F.
DOI：
10.1523/jneurosci.3886-12.2013
发表时间：
2013-03-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
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通讯作者：
Song MR
影响因子：
25
作者：
Bissière, S;Humeau, Y;Lüthi, A
通讯作者：
Lüthi, A
影响因子：
5.3
作者：
Brown, P;Oliviero, A;Di Lazzaro, V
通讯作者：
Di Lazzaro, V