Intra-aneurysmal embolization of cellulose porous beads to regenerate vessel wall: an experimental study
Intra-aneurysmal embolization of cellulose porous beads to regenerate vessel wall: an experimental study
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纤维素多孔珠动脉瘤内栓塞再生血管壁：实验研究
DOI：
10.1007/s00234-020-02440-w
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发表时间：
2020
期刊：
影响因子：
2.8
通讯作者：
Nakada Mitsutoshi
中科院分区：
文献类型：
--
作者：
Hasegawa Takayuki;Uchiyama Naoyuki;Sano Hiroki;Kawahara Yosuke;Nakada Mitsutoshi
目的：虽然可拆卸线圈治疗颅内脑动脉瘤已被广泛接受，但线圈的压实和再通问题仍未得到解决。如果能在动脉瘤的颈孔处再生血管壁，从而减少进入动脉瘤的血流量，那么动脉瘤的复发率就会降低。为此，我们拟将纤维素多孔珠（CPBs）植入大鼠颈外动脉（ECA）动脉瘤模型，研究其促进血管壁再生的效果。方法采用大鼠动脉瘤模型，观察结扎后ECA囊内插入CPBs后组织的反应。于植入后第14、42、84和180天取出囊，进行常规和免疫组织化学检查。我们评估了ECA囊内的组织反应，并观察了血管壁再生的进展。结果在植入CPB的动脉瘤颈口，在第14天观察到一层再生的α-平滑肌动蛋白阳性梭形细胞。再生细胞层逐渐增厚至第42天，此后厚度保持不变，直至第180天。第14天在颈孔也出现一层因子viii阳性细胞，并覆盖整个孔，直到第180天。cpb稳定地定位在囊内，没有降解或炎症迹象。结论cpbs是一种很有前景的栓塞材料，可以在动脉瘤颈口诱导稳定的血管壁再生，而周围无炎症反应。
PurposeAlthough the treatment of intracranial cerebral aneurysms with detachable coils is now widely accepted, the problem of coil compaction and recanalization remains unsolved. If the vessel wall can be regenerated at the neck orifice of an aneurysm, thereby reducing the blood flow into the aneurysm, the recurrence rate of the aneurysm would decrease. Accordingly, we aimed to insert cellulose porous beads (CPBs) into rat models of external carotid artery (ECA) aneurysm and study their efficacy in promoting vessel wall regeneration.MethodsUsing a rat aneurysm model, we examined the tissue response to CPBs that were inserted into the ligated ECA sac of rats. The sacs were removed on days 14, 42, 84, and 180 after insertion and subjected to conventional and immunohistochemical examination. We evaluated the tissue response in the ECA sacs and observed the vessel wall regeneration progress.ResultsAt the neck orifice of the aneurysm in which the CPB was inserted, a layer of regenerating α-smooth muscle actin-positive spindle cells was observed on day 14. The regenerative cell layer gradually thickened until day 42 and, thereafter, the thickness remained unchanged until day 180. A monolayer of factor VIII-positive cells also appeared at the neck orifice on day 14 and covered the entire orifice until day 180. The CPBs were stably localized in the sac without degradation or signs of inflammation.ConclusionCPBs may be promising as embolic materials that can induce stable vessel wall regeneration at the neck orifice of an aneurysm without surrounding inflammatory reactions.
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胶原填充的互锁可拆卸弹簧圈在猪实验性动脉瘤消融中的组织学效应。
DOI：
--
发表时间：
1996
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
R. Dawson;G. Shengelaia;A. Krisht;G. Bonner
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DOI：
--
发表时间：
2013
期刊：
Journal of Biomedical Materials Research. Part B - Applied biomaterials
影响因子：
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作者：
T. Kodama;H. Iwata
通讯作者：
H. Iwata
纤维素多孔珠栓塞，I：实验研究。
DOI：
--
发表时间：
1996
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
J. Hamada;Yukitaka Ushio;K. Kazekawa;T. Tsukahara;Nobuo Hashimoto;H. Iwata
通讯作者：
H. Iwata
纤维素多孔珠栓塞，II：临床试验。
DOI：
--
发表时间：
1996
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
J. Hamada;Y. Kai;S. Nagahiro;Nobuo Hashimoto;H. Iwata;Yukitaka Ushio
通讯作者：
Yukitaka Ushio
颅内动脉瘤在弹簧圈栓塞后随着时间的推移反复重新开放：影像学特征和治疗结果
影响因子：
2.8
作者：
W. J. V. Rooij;M. Sprengers;M. Sluzewski;G. Beute
通讯作者：
G. Beute