Growing Pains: The Need for Engineered Platforms to Study Growth Plate Biology.
Growing Pains: The Need for Engineered Platforms to Study Growth Plate Biology.
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DOI：
10.1002/adhm.202200471
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发表时间：
2022-10
影响因子：
10
通讯作者：
Harley, Brendan A. C.
中科院分区：
文献类型：
--
作者：
Tiffany, Aleczandria S.;Harley, Brendan A. C.
生长板，或称为骺板，是高度特化的软骨组织，负责儿童和青少年的骨骼纵向生长。位于生长板内的软骨细胞被组织成三个对其正常功能至关重要的不同区域。对生长板关键特征进行建模可能为开发先进的组织工程策略以及软骨和骨再生医学应用提供途径，并为研究与疾病进展相关的过程提供一个平台。在这篇综述中，我们首先简要介绍生长板及其在骨骼发育中的作用。我们讨论生长板的损伤和疾病，以及与重塑和疾病进展相关的生理和病理机制。然后我们聚焦于生长板生物学，即其结构和细胞外基质组织、驻留细胞类型以及生长因子信号传导。接下来，我们讨论开发三维生物材料模型以在体外研究生长板生物学和疾病各方面的机遇和挑战。最后，我们描述了日益复杂的生长板体外生物材料模型在研究生长板重塑的时空方面、探究生长板生物学背后的多细胞信号传导以及开发解决体内肌肉骨骼组织工程应用关键障碍的平台方面的机遇。
生长板是高度有序的软骨组织，负责儿童和青少年的骨骼生长。其发育特性是组织工程的一个令人兴奋的激励因素。然而，这种发育中的组织的生物材料模型非常少。在这篇综述中，我们讨论生长板生物学，并呼吁研究人员开发材料来对这种动态组织进行建模和研究。
Growth plates, or physis, are highly specialized cartilage tissues responsible for longitudinal bone growth in children and adolescents. Chondrocytes that reside in growth plates are organized into three distinct zones essential for proper function. Modeling key features of growth plates may provide an avenue to develop advanced tissue engineering strategies and perspectives for cartilage and bone regenerative medicine applications and a platform to study processes linked to disease progression. In this review, we first provide a brief introduction of the growth plates and their role in skeletal development. We discuss injuries and diseases of the growth plates as well as physiological and pathological mechanisms associated with remodeling and disease progression. We then focus on growth plate biology, namely its architecture and extracellular matrix organization, resident cell types, and growth factor signaling. Next, we discuss opportunities and challenges for developing three-dimensional biomaterial models to study aspects of growth plate biology and disease in vitro. Finally, we describe opportunities for increasingly sophisticated in vitro biomaterial models of the growth plate to study spatiotemporal aspects of growth plate remodeling, to investigate multicellular signaling underlying growth plate biology, and to develop platforms that address key roadblocks to in vivo musculoskeletal tissue engineering applications. The growth plates are highly organized cartilage tissues responsible for skeletal growth in children and adolescents. Their developmental nature is an exciting motivator for tissue engineering. However, there exist very few biomaterial models of this developing tissue. In this review, we discuss growth plate biology and call on researchers to develop materials to model and study this dynamic tissue.
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DOI：
10.1083/jcb.35.1.81
发表时间：
1967-10
期刊：
The Journal of cell biology
影响因子：
--
作者：
Anderson HC
通讯作者：
Anderson HC
影响因子：
18.2
作者：
Bergholt, Mads S.;St-Pierre, Jean-Philippe;Offeddu, Giovanni S.;Parmar, Paresh A.;Albro, Michael B.;Puetzer, Jennifer L.;Oyen, Michelle L.;Stevens, Molly M.
通讯作者：
Stevens, Molly M.
DOI：
10.1073/pnas.67.3.1513
发表时间：
1970-01-01
影响因子：
11.1
作者：
ALI, SY;SAJDERA, SW;ANDERSON, HC
通讯作者：
ANDERSON, HC
影响因子：
4.1
作者：
Andrade, Anenisla C.;Nilsson, Ola;Baron, Jeffrey
通讯作者：
Baron, Jeffrey
DOI：
10.1073/pnas.192291499
发表时间：
2002-09-17
影响因子：
11.1
作者：
Alsberg, E;Anderson, KW;Mooney, DJ
通讯作者：
Mooney, DJ