Assessment of exposure to alcohol vapor from alcohol-based hand rubs.
Assessment of exposure to alcohol vapor from alcohol-based hand rubs.
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DOI：
10.3390/ijerph9030868
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发表时间：
2012-03
影响因子：
--
通讯作者：
Thomas O
中科院分区：
文献类型：
--
作者：
Bessonneau V;Thomas O
这项研究评估了手部消毒期间吸入的酒精剂量。使用两种手部消毒程序对两种类型的洗手液进行了实验。通过 K2Cr2O7 和 H2SO4 的混合物鼓泡，每 10 秒从呼吸区采集一次空气样本。在醇存在下重铬酸根离子被还原，随后进行紫外-可见分光光度测定。重铬酸盐吸收峰的强度差异用于量化以乙醇当量表示的酒精浓度。在卫生手部消毒过程中，两次搓手液的平均乙醇当量浓度在 20-30 秒左右达到峰值（搓手液 1 为 14.3 ± 1.4 mg/L，搓手液 2 为 13.2 ± 0.7 mg/L）。在外科手部消毒过程中，双手揉搓同时发现两个峰值（40 秒和 80 秒）。洗手液 1 的最高平均浓度为 20.2 ± 0.9 mg/L，洗手液 2 的最高平均浓度为 18.1 ± 0.9 mg/L。对于洗手液 1，根据吸入流量为 24 L/min、吸收率为 62% 的乙醇计算，一次卫生手消毒后的总吸收剂量为 46.5 mg，一次手术手消毒后的总吸收剂量为 203.9 mg。尽管使用 ABHR 会导致极低剂量的吸收，但突然、反复吸入高浓度酒精会引发可能对健康产生不利影响的问题。
This study assessed the inhaled dose of alcohol during hand disinfection. Experiments were conducted with two types of hand rub using two hand disinfection procedures. Air samples were collected every 10 s from the breathing zone, by bubbling through a mixture of K2Cr2O7 and H2SO4. The reduction of dichromate ions in the presence of alcohols was followed by UV-vis spectrophotometry. The difference in intensity of the dichromate absorption peak was used to quantify the alcohol concentration expressed in ethanol equivalent. During hygienic hand disinfection, the mean ethanol equivalent concentrations peaked at around 20–30 s for both hand rubs (14.3 ± 1.4 mg/L for hand rub 1 and 13.2 ± 0.7 mg/L for hand rub 2). During surgical hand disinfection, two peaks were found at the same time (40 and 80 s) for both hand rubs. The highest mean concentrations were 20.2 ± 0.9 mg/L for hand rub 1 and 18.1 ± 0.9 mg/L for hand rub 2. For hand rub 1, the total absorbed doses, calculated from ethanol with an inhalation flow of 24 L/min and an absorption rate of 62%, were 46.5 mg after one hygienic hand disinfection and 203.9 mg after one surgical hand disinfection. Although the use of ABHRs leads to the absorption of very low doses, sudden, repeated inhalation of high alcohol concentrations raises the question of possible adverse health effects.
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影响因子：
3.6
作者：
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