Inactivation of the Ventrolateral Orbitofrontal Cortex Impairs Flexible Use of Safety Signals.
Inactivation of the Ventrolateral Orbitofrontal Cortex Impairs Flexible Use of Safety Signals.
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DOI：
10.1016/j.neuroscience.2018.03.037
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发表时间：
2018-05-21
期刊：
影响因子：
3.3
通讯作者：
Christianson JP
中科院分区：
文献类型：
--
作者：
Sarlitto MC;Foilb AR;Christianson JP
Survival depends on adaptation to shifting environmental risks and opportunities. Regarding risks, the mechanisms which permit acquisition, recall, and flexible use of aversive associations is poorly understood. Drawing on the evidence that the orbital frontal cortex is critical to integrating outcome expectancies with flexible appetitive behavioral responses, we hypothesized that OFC would contribute to behavioral flexibility within an aversive learning domain. We introduce a fear conditioning procedure in which adult male rats were presented with shock-paired conditioned stimulus (CS+) or a safety cue (CS−). In a recall test, rats exhibit greater freezing to the CS+ than the CS−. Temporary inactivation of the ventrolateral OFC with muscimol prior to conditioning did not affect later discrimination, but inactivation after learning and prior to recall impaired discrimination between safety and danger cues. This result complements prior research in the appetitive domain and suggests that the OFC plays a general role in behavioral flexibility regardless of the valence of the CS.
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影响因子：
4.7
作者：
Jovanovic T;Kazama A;Bachevalier J;Davis M
通讯作者：
Davis M
影响因子：
10.6
作者：
Christianson, John P.;Jennings, Joshua H.;Ragole, Thomas;Flyer, Johana G. N.;Benison, Alexander M.;Barth, Daniel S.;Watkins, Linda R.;Maier, Steven F.
通讯作者：
Maier, Steven F.
GABA和MUSCIMOL是学习和记忆中可逆的灭活工具。
影响因子：
3.1
作者：
Majchrzak M;Di Scala G
通讯作者：
Di Scala G
影响因子：
4.6
作者：
Grillon, C;Morgan, CA
通讯作者：
Morgan, CA
影响因子：
2
作者：
Foilb, Allison R.;Bals, Julia;Christianson, John P.
通讯作者：
Christianson, John P.