The transcriptomic signature of different sexes in two protogynous hermaphrodites: Insights into the molecular network underlying sex phenotype in fish.
The transcriptomic signature of different sexes in two protogynous hermaphrodites: Insights into the molecular network underlying sex phenotype in fish.
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DOI：
10.1038/s41598-018-21992-9
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发表时间：
2018-02-23
影响因子：
4.6
通讯作者：
Tsigenopoulos CS
中科院分区：
文献类型：
--
作者：
Tsakogiannis A;Manousaki T;Lagnel J;Sterioti A;Pavlidis M;Papandroulakis N;Mylonas CC;Tsigenopoulos CS
由于鱼类生殖系统的多样性和性别决定机制的灵活性，鱼类的性别分化一直是一个令人困惑的问题。鲷科，硬骨鱼科，反映了这种显着的多样性的性机制中发现的鱼类。我们的目的是捕捉转录组签名的不同性别的两个原生雌雄同体的sparids，共同pandora Pagellus pagrinus和红色的鲷Pagrus pagrus，以阐明在这些生物体中的分子网络有助于女性或男性表型。通过RNA测序，我们研究了两种物种大脑和性腺中基因表达的性别特异性差异。分析揭示了这些雌性先熟鱼之间共同的雄性和雌性特异性基因/通路。在大脑中发现的有限的性别差异表明了一个具有性可塑性的组织，相反，在性腺中观察到的大量性别偏见基因反映了转化组织的功能分化，无论是男性还是女性。一个共同的“船员”的知名分子的球员是采取行动，以保持任何性别身份的性腺在这些鱼。最后，这项研究奠定了基础，更深入地了解复杂的性别分化过程中的两个物种的进化显着的生殖系统。
Sex differentiation is a puzzling problem in fish due to the variety of reproductive systems and the flexibility of their sex determination mechanisms. The Sparidae, a teleost family, reflects this remarkable diversity of sexual mechanisms found in fish. Our aim was to capture the transcriptomic signature of different sexes in two protogynous hermaphrodite sparids, the common pandora Pagellus erythrinus and the red porgy Pagrus pagrus in order to shed light on the molecular network contributing to either the female or the male phenotype in these organisms. Through RNA sequencing, we investigated sex-specific differences in gene expression in both species’ brains and gonads. The analysis revealed common male and female specific genes/pathways between these protogynous fish. Whereas limited sex differences found in the brain indicate a sexually plastic tissue, in contrast, the great amount of sex-biased genes observed in gonads reflects the functional divergence of the transformed tissue to either its male or female character. Α common “crew” of well-known molecular players is acting to preserve either sex identity of the gonad in these fish. Lastly, this study lays the ground for a deeper understanding of the complex process of sex differentiation in two species with an evolutionary significant reproductive system.
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影响因子：
4.6
作者：
Casas L;Saborido-Rey F;Ryu T;Michell C;Ravasi T;Irigoien X
通讯作者：
Irigoien X
DOI：
10.1073/pnas.1010442107
发表时间：
2010-12-07
影响因子：
11.1
作者：
Desjardins, Julie K.;Klausner, Jill Q.;Fernald, Russell D.
通讯作者：
Fernald, Russell D.
影响因子：
2.7
作者：
Chiang, EFL;Pai, CI;Chung, BC
通讯作者：
Chung, BC
影响因子：
2.7
作者：
Baron, Daniel;Houlgatte, Remi;Guiguen, Yann
通讯作者：
Guiguen, Yann
影响因子：
14.9
作者：
UniProt Consortium
通讯作者：
UniProt Consortium