Emerging roles for AQP in mammalian extracellular vesicles.
Emerging roles for AQP in mammalian extracellular vesicles.
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DOI：
10.1016/j.bbamem.2021.183826
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发表时间：
2022-03-01
期刊：
影响因子：
--
通讯作者：
Devitt A
中科院分区：
文献类型：
--
作者：
Clarke-Bland CE;Bill RM;Devitt A
水通道蛋白（AQP）领域的最新研究已经确定了多种AQP在细胞外囊泡（EV）中的作用。虽然仍处于起步阶段，但该领域的知识越来越多; EV中的AQP已被建议作为疾病的生物标志物，作为药物靶点，并显示出作为治疗药物的潜力。为了在这一领域取得进一步进展，必须更好地了解EV中的AQP。在这里，我们总结了目前的知识的存在和功能的水通道蛋白在EV和假设他们的角色在健康和疾病。细胞外囊泡（EV）将供体细胞的货物运送到受体细胞，调节生理。水通道蛋白（AQP）是EV在健康和疾病状态下的组成部分，可以从体液中分离。
Recent research in the aquaporin (AQP) field has identified a role for diverse AQPs in extracellular vesicles (EV). Though still in its infancy, there is a growing body of knowledge in the area; AQPs in EV have been suggested as biomarkers for disease, as drug targets and show potential as therapeutics. To advance further in this field, AQPs in EV must be better understood. Here we summarize current knowledge of the presence and function of AQPs in EV and hypothesise their roles in health and disease. Extracellular vesicles (EV) deliver cargo from donor to recipient cells, modulating physiology Aquaporins (AQP) are components of EV in both healthy and diseased states and can be isolated from body fluids Potential functional roles of EV-bound AQP in donor and recipient cells and in EV themselves are discussed.
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DOI：
10.12659/msm.898190
发表时间：
2016-12-08
期刊：
Medical science monitor : international medical journal of experimental and clinical research
影响因子：
--
作者：
Chen JQ;Zhang CC;Jiang SN;Lu H;Wang W
通讯作者：
Wang W
影响因子：
3.9
作者：
Akers, Johnny C.;Ramakrishnan, Valya;Kim, Ryan;Phillips, Shirley;Kaimal, Vivek;Mao, Ying;Hua, Wei;Yang, Isaac;Fu, Chia-Chun;Nolan, John;Nakano, Ichiro;Yang, Yuanfan;Beaulieu, Martin;Carter, Bob S.;Chen, Clark C.
通讯作者：
Chen, Clark C.
DOI：
10.1016/j.jconrel.2015.07.030
发表时间：
2015-12-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Batrakova EV;Kim MS
通讯作者：
Kim MS
影响因子：
6.2
作者：
Brites, Dora
通讯作者：
Brites, Dora
影响因子：
15.9
作者：
Bai, CX;Fukuda, N;Verkman, AS
通讯作者：
Verkman, AS