High serum uric acid levels are a protective factor against unfavourable neurological functional outcome in patients with ischaemic stroke.
High serum uric acid levels are a protective factor against unfavourable neurological functional outcome in patients with ischaemic stroke.
复制标题
高血清尿酸水平是缺血性卒中患者不良神经功能结果的保护因素
DOI：
10.1177/0300060517752996
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发表时间：
2018-05
期刊：
影响因子：
--
通讯作者：
Sheng WL
中科院分区：
文献类型：
--
作者：
Wang YF;Li JX;Sun XS;Lai R;Sheng WL
目的探讨急性缺血性脑卒中患者发病时血尿酸水平与预后的关系。方法回顾性分析2008年8月至2012年11月在我中心住院的1166例缺血性脑卒中患者的结局。分析血清尿酸水平与预后的相关性。结果男性血尿酸水平高于女性，神经功能预后优于女性。血尿酸水平与不良神经功能结局之间存在很强的负相关。广义估计方程分析显示，较高的血清尿酸水平（>237 µmol/L）是男性患者神经功能结局的保护因素，而不是女性患者。在ORG 10172急性卒中治疗分类亚型的5项试验中，只有大动脉粥样硬化亚型患者的血清尿酸水平对神经系统结局具有显著的保护作用。结论我们的研究表明，高血清尿酸水平是男性和缺血性脑卒中患者大动脉粥样硬化亚型的一个重要保护因素。这有助于确定血清尿酸水平对急性缺血性脑卒中神经功能预后的预测价值。
Objective We aimed to evaluate the association between serum uric acid levels at the onset and prognostic outcome in patients with acute ischaemic stroke. Methods We retrospectively analysed the outcomes of 1166 patients with ischaemic stroke who were hospitalized in our centre during August 2008 to November 2012. Correlations of serum uric acid levels and prognostic outcomes were analysed. Results Men had higher serum uric acid levels and better neurological functional outcomes compared with women. There was a strong negative correlation between serum uric acid levels and unfavourable neurological functional outcomes. Generalized estimated equation analysis showed that a higher serum uric acid level (>237 µmol/L) was a protective factor for neurological functional outcome in male, but not female, patients. Among five trial of ORG 10172 in acute stroke treatment classification subtypes, only patients with the large-artery atherosclerosis subtype had a significant protective effect of serum uric acid levels on neurological outcome. Conclusions Our study shows that high serum uric acid levels are a significant protective factor in men and in the large-artery atherosclerosis subtype in patients with ischaemic stroke. This is helpful for determining the prognostic value of serum uric acid levels for neurological outcome of acute ischaemic stroke.
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