Measuring virgin female aggression in the female intruder test (FIT): effects of oxytocin, estrous cycle, and anxiety.
Measuring virgin female aggression in the female intruder test (FIT): effects of oxytocin, estrous cycle, and anxiety.
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DOI：
10.1371/journal.pone.0091701
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Neumann ID
中科院分区：
文献类型：
--
作者：
de Jong TR;Beiderbeck DI;Neumann ID
我们社会中暴力和侵略的代价刺激了对侵略的预测因素和原因的科学研究。大多数研究都集中在男性身上，因为在大多数物种中，男性被认为比女性更具攻击性。然而，女孩和年轻女性的攻击性行为比率相当高，目前在西方社会正在上升。从男性到年轻的非母体女性的科学结果的推断是先验的有限的，这是基于参与攻击的大脑区域和神经递质功能的深刻性别差异。因此，我们建立了一种评估年轻处女雌性大鼠攻击行为的范式，即雌性入侵者测试(FIT)。我们发现，大约40%的未经操纵的成年(10-11周龄)雌性Wistar大鼠在Fit期间攻击入侵者雌性大鼠，与它们的发情期或入侵者无关。此外，被选为高焦虑行为(HAB)的青春期(7-8周)雌性大鼠比未被选择的(NAB)或低焦虑(LAB)大鼠表现出显著更多的攻击性。脑室注射催产素(OXT，0.1微克/5微克L)可抑制成年NAB和LAB的攻击行为，但不能抑制HAB雌性小鼠的攻击行为。与非攻击性NAB大鼠相比，攻击其入侵者的青春期NAB大鼠下丘脑攻击区域的PERK免疫反应性(IR)增加，而下丘脑室旁核OXT神经元的PERK-IR降低。总而言之，年轻处女雌性大鼠的攻击行为在一定程度上取决于特质焦虑，而且似乎受到相当大的控制。
The costs of violence and aggression in our society have stimulated the scientific search for the predictors and causes of aggression. The majority of studies have focused on males, which are considered to be more aggressive than females in most species. However, rates of offensive behavior in girls and young women are considerable and are currently rising in Western society. The extrapolation of scientific results from males to young, non-maternal females is a priori limited, based on the profound sex differences in brain areas and functioning of neurotransmitters involved in aggression. Therefore, we established a paradigm to assess aggressive behavior in young virgin female rats, i.e. the female intruder test (FIT). We found that approximately 40% of un-manipulated adult (10–11 weeks old) female Wistar rats attack an intruder female during the FIT, independent of their estrous phase or that of their intruder. In addition, adolescent (7–8 weeks old) female rats selected for high anxiety behavior (HABs) displayed significantly more aggression than non-selected (NAB) or low-anxiety (LAB) rats. Intracerebroventricular infusion of oxytocin (OXT, 0.1 µg/5 µl) inhibited aggressive behavior in adult NAB and LAB, but not HAB females. Adolescent NAB rats that had been aggressive towards their intruder showed increased pERK immunoreactivity (IR) in the hypothalamic attack area and reduced pERK-IR in OXT neurons in the paraventricular hypothalamic nucleus compared to non-aggressive NAB rats. Taken together, aggressive behavior in young virgin female rats is partly dependent on trait anxiety, and appears to be under considerable OXT control.
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影响因子：
8.2
作者：
Bartz JA;Zaki J;Bolger N;Hollander E;Ludwig NN;Kolevzon A;Ochsner KN
通讯作者：
Ochsner KN
DOI：
10.1111/j.1749-6632.1992.tb34382.x
发表时间：
1992-06-12
期刊：
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES
影响因子：
--
作者：
FERRIS, CF;FOOTE, KB;INSEL, TR
通讯作者：
INSEL, TR
影响因子：
2.7
作者：
Ferris, CF
通讯作者：
Ferris, CF
影响因子：
4.8
作者：
Fuxjager, Matthew J.;Oyegbile, Temitayo O.;Marler, Catherine A.
通讯作者：
Marler, Catherine A.
影响因子：
3.4
作者：
Calcagnoli, Federica;de Boer, Sietse F.;Koolhaas, Jaap M.
通讯作者：
Koolhaas, Jaap M.