Functional Connectivity of the Chemosenses: A Review.

Functional Connectivity of the Chemosenses: A Review.
复制标题

化学的功能连通性:评论。

DOI:
10.3389/fnsys.2022.865929
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发表时间:
2022
影响因子:
3
通讯作者:
Scheinost, Dustin
Scheinost, Dustin
中科院分区:
医学3区
文献类型:
--
作者:
Farruggia, Michael C.;Pellegrino, Robert;Scheinost, Dustin

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功能连接方法长期以来一直用于认知神经科学,以建立大脑区域之间的通信路径。然而,利用这些分析来更好地了解大脑如何处理化学感觉信息仍然处于起步阶段。在这篇综述中,我们对嗅觉、味觉和化学感觉的所有功能连接性论文进行了文献检索,共发现了103篇文章。这些出版物主要使用基于种子的功能连接和心理生理相互作用的方法,以及有效的连接方法,如格兰杰因果关系,动态因果模型和结构方程模型。无论模态,研究主要集中在阐明神经相关的刺激质量,如身份,愉快,强度,与任务为基础的范式最常实施。我们呼吁在预测建模中进一步采用“无模型”或数据驱动的方法,以构建不受先验假设影响的大脑行为关系,而不仅仅是基于潜在的不可复制的文献。此外,我们注意到一个相对缺乏的休息状态的文献,这可以用来更好地了解化学感觉网络的影响较小的运动伪影通过味觉或嗅觉范式。最后,我们注意到缺乏基因组学数据,这可以澄清个体和遗传差异的化学感觉知觉。
Functional connectivity approaches have long been used in cognitive neuroscience to establish pathways of communication between and among brain regions. However, the use of these analyses to better understand how the brain processes chemosensory information remains nascent. In this review, we conduct a literature search of all functional connectivity papers of olfaction, gustation, and chemesthesis, with 103 articles discovered in total. These publications largely use approaches of seed-based functional connectivity and psychophysiological interactions, as well as effective connectivity approaches such as Granger Causality, Dynamic Causal Modeling, and Structural Equation Modeling. Regardless of modality, studies largely focus on elucidating neural correlates of stimulus qualities such as identity, pleasantness, and intensity, with task-based paradigms most frequently implemented. We call for further “model free” or data-driven approaches in predictive modeling to craft brain-behavior relationships that are free from a priori hypotheses and not solely based on potentially irreproducible literature. Moreover, we note a relative dearth of resting-state literature, which could be used to better understand chemosensory networks with less influence from motion artifacts induced via gustatory or olfactory paradigms. Finally, we note a lack of genomics data, which could clarify individual and heritable differences in chemosensory perception.
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