Glutamate-like immunoreactivity is present within cholinergic neurons of the laterodorsal tegmental and pedunculopontine nuclei.

Glutamate-like immunoreactivity is present within cholinergic neurons of the laterodorsal tegmental and pedunculopontine nuclei.
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谷氨酸样免疫反应性存在于背侧被盖核和桥脚核的胆碱能神经元内。

DOI:
10.1007/978-1-4757-0145-6_5
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发表时间:
1991
影响因子:
--
通讯作者:
Grant,SJ
Grant,SJ
中科院分区:
医学4区
文献类型:
--
作者:
Clements,JR;Toth,DD;Highfield,DA;Grant,SJ

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在过去的十年中,胆碱能神经元的功能组织已经主导了基底前脑的研究。脑中的胆碱能神经元,不包括运动神经元和中间神经元,存在于两个空间上分离的组中(Armstrong et al.,1983年,Mesulam等人,1984年)。位于基底前脑中的吻侧组由于其皮质足投射而受到大量关注(Mesulam等人,1984)及其在阿尔茨海默病中的变性(Coyle等,1983年)。尾侧组存在于脑桥被盖内的背侧被盖核(LDT)和脚桥核(PPT)中(Vincent等人,1983; Mesulam等人,1984; Satoh和Fibiger,1986),并且是基底前脑、丘脑和脑干的胆碱能神经支配的来源(Sofroniew等人,1985; Hallenger等人,1987; Maley等人,1988; Rye等人,1988; Jones,1990)。
For the last decade the functional organization pf cholinergic neurons has dominated studies of the basal forebrain. Cholinergic neurons in the brain, exclusive of motor neurons and interneurons, are found in two spatially separate groups (Armstrong et al., 1983, Mesulam et al., 1984). The rostral group, located in the basal forebrain, has received substantial attention because of its corticopedal projections (Mesulam et al., 1984) and its’ degeneration in Alzheimer’s disease (Coyle et al., 1983). The caudal group is found in the laterodorsal tegmental nucleus (LDT) and pedunculopontine nucleus (PPT) within the pontine tegmentum (Vincent et al., 1983; Mesulam et al., 1984; Satoh and Fibiger, 1986), and is the source of cholinergic innervation to the basal forebrain, thalamus and brainstem (Sofroniew et al., 1985; Hallenger et al., 1987; Maley et al., 1988; Rye et al., 1988; Jones, 1990).
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