Serum uric acid levels and the risk of impaired fasting glucose: a prospective study in adults of north China.
Serum uric acid levels and the risk of impaired fasting glucose: a prospective study in adults of north China.
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血清尿酸水平与空腹血糖受损的风险：华北成人的前瞻性研究
DOI：
10.1371/journal.pone.0084712
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Wu S
中科院分区：
文献类型：
--
作者：
Liu Y;Jin C;Xing A;Liu X;Chen S;Li D;Feng P;Liu J;Li Z;Wu S
目的前瞻性研究中国成人血清尿酸（SUA）水平与空腹血糖受损（IFG）发生率的关系。方法 我们对 13,328 名没有糖尿病和 IFG 的女性和 41,350 名男性进行了评估。根据 SUA 基线水平将参与者分为五等分。分析数据以检查 SUA 水平与 IFG 发生率之间的关联。在调整已知风险因素后，我们使用 Cox 回归模型来估计 IFG 的相对风险。结果 对于男性，SUA 的第二个五分位数的 IFG 累积发生率最低 (29.9%)； SUA 的第五个五分位的 IFG 累积发生率最高 (35.6%)。经Cox回归校正后，第一四分位数和第四四分位数的IFG累积发生率高于第二五分位数，HR分别为1.11（1.05-1.17）和1.07（1.01-1.13）。对于女性来说，SUA 的第一个四分位的 IFG 累积发生率最低（20.7%），而 SUA 的第五个五分位的 IFG 累积发生率最高（30.0%）。然而，经Cox回归调整后，不同五分位数之间的IFG没有显着差异。结论 这项前瞻性研究的结果表明，男性发生 IFG 的风险较高，与 SUA 浓度低或高相关。这些关系独立于其他已知的风险因素。对于女性来说，发生 IFG 的风险与 SUA 浓度没有显着相关性。排除患有高血压或高脂血症的参与者的分析以及对按年龄分层的参与者的分析得出了相似的结论。
Objective To prospectively investigate the association between serum uric acid (SUA) level and incidence of impaired fasting glucose (IFG) in adult Chinese. Methods We evaluated 13,328 women and 41,350 men without diabetes and IFG. The participants were classified into quintile according to baseline level of SUA. Data were analyzed to examine the association between SUA levels and the incidence of IFG. We used Cox regression models to estimate the relative risk of IFG after adjusting for known risk factors. Results For men, the second quintile of SUA has the lowest cumulative incidence of IFG (29.9%); the fifth quintile of SUA has the highest cumulative incidence of IFG (35.6%). After corrected with Cox regression, the first quartile and the fourth quartile have higher cumulative incidence of IFG than the second quintile, with the HR of 1.11(1.05-1.17) and 1.07(1.01-1.13), respectively. For women, the first quartile of SUA has the lowest cumulative incidence of IFG (20.7%), while the fifth quintile of SUA has the highest cumulative incidence of IFG (30.0%). However, there is no significant difference in IFG between different quintile after adjusted with Cox regression. Conclusions The results of this prospective study suggest that there is a higher risk of developing IFG in association with low or high SUA concentrations for men. These relationships were independent of other known risk factors. There is no significant correlation in the risk of developing IFG in association with SUA concentrations for women. Analyses excluding participants with hypertension or with hyperlipidemia and analyses with participants stratified by age reached similar conclusion.
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影响因子：
3.7
作者：
Wang A;Wu J;Zhou Y;Guo X;Luo Y;Wu S;Zhao X
通讯作者：
Zhao X
影响因子：
16.2
作者：
Perticone F;Sciacqua A;Perticone M;Arturi F;Scarpino PE;Quero M;Sesti G
通讯作者：
Sesti G
影响因子：
15.9
作者：
So, Alexander;Thorens, Bernard
通讯作者：
Thorens, Bernard
影响因子：
7.2
作者：
Yamada, T.;Fukatsu, M.;Joh, T.
通讯作者：
Joh, T.
影响因子：
158.5
作者：
CANNON, PJ;STASON, WB;LARAGH, JH
通讯作者：
LARAGH, JH