Multiscale bioprinting of vascularized models.
Multiscale bioprinting of vascularized models.
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DOI：
10.1016/j.biomaterials.2018.08.006
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发表时间：
2019-04
期刊：
影响因子：
14
通讯作者：
Khademhosseini A
中科院分区：
文献类型：
--
作者：
Miri AK;Khalilpour A;Cecen B;Maharjan S;Shin SR;Khademhosseini A
三维（3D）工程化组织构建体的存活和功能的基本先决条件是血管的建立。具有类似于体内结构的分层结构的血管网络的3D生物打印允许厚组织结构内的血液循环，以加速血管化并增强组织再生。组织构建体的成功快速血管化需要可灌注通道的制造与诱导构建体内的血管生成和毛细血管形成的功能性生物墨水之间的协同作用。3D生物打印技术和四维（4D）打印概念的组合，通过图案化促血管生成因子，可以为厚结构的植入提供新的解决方案。在这篇综述中，我们涵盖了目前的生物打印技术，用于血管化组织结构，血管从毛细血管到大血管，并讨论了如何实施这些方法来图案化促血管生成因子，以保持长期的，刺激控制的新毛细血管的形成。
A basic prerequisite for the survival and function of three-dimensional (3D) engineered tissue constructs is the establishment of blood vessels. 3D bioprinting of vascular networks with hierarchical structures that resemble in vivo structures has allowed blood circulation within thick tissue constructs to accelerate vascularization and enhance tissue regeneration. Successful rapid vascularization of tissue constructs requires synergy between fabrication of perfusable channels and functional bioinks that induce angiogenesis and capillary formation within constructs. Combinations of 3D bioprinting techniques and four-dimensional (4D) printing concepts through patterning proangiogenic factors may offer novel solutions for implantation of thick constructs. In this review, we cover current bioprinting techniques for vascularized tissue constructs with vasculatures ranging from capillaries to large blood vessels and discuss how to implement these approaches for patterning proangiogenic factors to maintain long-term, stimuli-controlled formation of new capillaries.
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