Concentrations of per- and polyfluoroalkyl substances (PFAS) in human placental tissues and associations with birth outcomes.
Concentrations of per- and polyfluoroalkyl substances (PFAS) in human placental tissues and associations with birth outcomes.
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DOI：
10.1016/j.chemosphere.2022.133873
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发表时间：
2022-05
期刊：
影响因子：
8.8
通讯作者：
Stapleton HM
中科院分区：
文献类型：
--
作者：
Hall SM;Zhang S;Hoffman K;Miranda ML;Stapleton HM
全氟烷基和多氟烷基物质（PFAS）是普遍存在的环境污染物，通常在人体血清中检测到。先前的研究已经观察到母体血清PFAS与不良妊娠和出生结局（如出生体重较低或先兆子痫）之间的相关性;然而，很少有研究探讨这些与出生结局和胎盘组织PFAS浓度的相关性。胎盘是健康妊娠的重要因素，可能参与PFAS生殖毒性的机制。我们的目标是测量胎盘PFAS浓度，并检查与出生结局的相关性（例如，出生体重、妊娠期）。胎盘样本（n=120）在分娩期间从达勒姆，北卡罗来纳州的健康妊娠，健康婴儿队列（HPHB）中招募的女性中收集。所有胎盘样本都含有可检测的全氟辛烷磺酸，其中全氟辛烷磺酸（PFOS）、全氟辛酸（PFOA）、全氟壬酸（PFNA）和全氟癸酸（PFDA）含量最多，检测频率最高（检测频率均>96%）。虽然胎盘PFAS浓度没有不同的婴儿性别，较高的PFAS水平，观察到胎盘从未经产的妇女，这表明奇偶性影响PFAS在胎盘中的积累。我们使用线性回归模型来研究胎盘PFAS和出生结局之间的关系。在调整胎次、烟草使用、母亲年龄和母亲种族后，我们发现胎盘PFOS与男婴胎龄出生体重较低和女婴胎龄出生体重较高相关。PFNA在胎龄出生体重方面也观察到类似的结果。这些基于婴儿性别的出生结局差异突出了需要探索妊娠期间PFAS毒性对男性和女性婴儿的机制差异。
Per- and polyfluoroalkyl substances (PFAS) are ubiquitous environmental contaminants commonly detected in human serum. Previous studies have observed associations between maternal serum PFAS and adverse pregnancy and birth outcomes such as lower birth weight or pre-eclampsia; however, few studies have explored these associations with birth outcomes and placental tissue PFAS concentration. The placenta is a vital contributor to a healthy pregnancy and may be involved in the mechanism of PFAS reproductive toxicity. Our goal was to measure placental PFAS concentrations and examine associations with birth outcomes (e.g., birth weight, gestational duration). Placenta samples (n=120) were collected during delivery from women enrolled in the Healthy Pregnancy, Healthy Baby cohort (HPHB) in Durham, North Carolina. All placenta samples contained detectable PFAS, with perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) being the most abundant and most frequently detected (all >96% detection frequency). While placental PFAS concentrations did not differ by infant sex, higher PFAS levels were observed in placenta from nulliparous women, suggesting that parity influences the accumulation of PFAS in the placenta. We used linear regression models to examine associations between placental PFAS and birth outcomes. After adjustment for parity, tobacco use, maternal age, and maternal race, we found that placental PFOS was associated with lower birth weight for gestational age in male infants and higher birth weight for gestational age in female infants. Similar findings were seen for PFNA for birth weight for gestational age. These differences in birth outcomes based on infant sex highlight a need to explore mechanistic differences in PFAS toxicity during gestation for male and female infants.
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影响因子：
4.5
作者：
Blake BE;Fenton SE
通讯作者：
Fenton SE
影响因子：
10.4
作者：
Calafat, Antonia M;Wong, Lee-Yang;Kuklenyik, Zsuzsanna;Reidy, John A;Needham, Larry L
通讯作者：
Needham, Larry L
DOI：
10.1016/j.reprotox.2009.02.012
发表时间：
2009-06
期刊：
Reproductive toxicology (Elmsford, N.Y.)
影响因子：
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作者：
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通讯作者：
Petropoulou SE
影响因子：
4.5
作者：
Bangma J;Szilagyi J;Blake BE;Plazas C;Kepper S;Fenton SE;C Fry R
通讯作者：
C Fry R
产前接触全氟烷基物质和多氟烷基物质 (PFAS) 以及胎盘转移效率与血清蛋白-PFAS 复合物解离常数之间的关联
影响因子：
11.4
作者：
Gao, Ke;Zhuang, Taifeng;Jiang, Guibin
通讯作者：
Jiang, Guibin