Totally tubular: the mystery behind function and origin of the brain ventricular system.
Totally tubular: the mystery behind function and origin of the brain ventricular system.
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DOI：
10.1002/bies.200800207
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发表时间：
2009-04
期刊：
影响因子：
4
通讯作者：
Sive, Hazel
中科院分区：
文献类型：
--
作者：
Lowery, Laura Anne;Sive, Hazel
脊椎动物大脑的一个独特特征是脑室系统，这是一系列相互连接的空腔，充满脑脊液（CSF）并被神经上皮包围。虽然脑脊液对于成人大脑功能和胚胎大脑发育都至关重要，但脑室系统的发育和功能尚不清楚。在这篇综述中，我们讨论了脊椎动物大脑为何有脑室及其起源之谜。当神经上皮经历形态发生时，脑室系统从神经管腔发育而来。描述了该个体发育的分子机制。我们讨论成人和胚胎脑室的可能功能，以及与脑脊液和脑室异常相关的主要大脑缺陷。我们得出的结论是，脊椎动物利用其神经管形成了重要的脑室系统。
A unique feature of the vertebrate brain is the brain ventricular system, a series of connected cavities which are filled with cerebrospinal fluid (CSF) and surrounded by neuroepithelium. While CSF is critical for both adult brain function and embryonic brain development, neither development nor function of the brain ventricular system is fully understood. In this review, we discuss the mystery of why vertebrate brains have ventricles, and whence they originate. The brain ventricular system develops from the lumen of the neural tube, as the neuroepithelium undergoes morphogenesis. The molecular mechanisms underlying this ontogeny are described. We discuss possible functions of both adult and embryonic brain ventricles, as well as major brain defects that are associated with CSF and brain ventricular abnormalities. We conclude that vertebrates have taken advantage of their neural tube to form the essential brain ventricular system.
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影响因子：
2.7
作者：
DESMOND, ME;JACOBSON, AG
通讯作者：
JACOBSON, AG
影响因子：
7.2
作者：
Bloom, SL;Bloom, DD;Twickler, DM
通讯作者：
Twickler, DM
影响因子：
2.7
作者：
AakuSaraste, E;Hellwig, A;Huttner, WB
通讯作者：
Huttner, WB
影响因子：
--
作者：
DESMOND, ME
通讯作者：
DESMOND, ME
DOI：
10.1016/0002-9378(91)90530-5
发表时间：
1991-03-01
影响因子：
9.8
作者：
BROMLEY, B;FRIGOLETTO, FD;BENACERRAF, BR
通讯作者：
BENACERRAF, BR