Nonoptimal Vaginal Microbiota After Azithromycin Treatment for Chlamydia trachomatis Infection.
Nonoptimal Vaginal Microbiota After Azithromycin Treatment for Chlamydia trachomatis Infection.
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DOI：
10.1093/infdis/jiz499
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发表时间：
2020-02-03
期刊：
影响因子：
--
通讯作者：
Ravel J
中科院分区：
文献类型：
--
作者：
Tamarelle J;Ma B;Gajer P;Humphrys MS;Terplan M;Mark KS;Thiébaut ACM;Forney LJ;Brotman RM;Delarocque-Astagneau E;Bavoil PM;Ravel J
我们对 149 名基线时患有生殖器沙眼衣原体感染的女性的阴道微生物群的组成和结构进行了表征，这些女性在抗生素治疗后每季度进行为期 9 个月的随访。诊断时，阴道微生物群以惰性乳杆菌或多种细菌性阴道病相关细菌（包括阴道加德纳菌）为主。有趣的是，在阿奇霉素治疗（1 g 单剂量）后，惰性 L. iners 占主导地位的群落最为常见，这与观察到的惰性 L. iners 对阿奇霉素的相对耐药性一致。以惰性乳杆菌为主的群落与沙眼衣原体感染风险增加有关，这表明抗生素治疗对阴道微生物群的影响可能有利于再次感染。这些结果支持了双重需要，即考虑抗生素治疗对阴道微生物群的潜在干扰作用，并制定保护和恢复最佳阴道微生物群的策略。用于治疗沙眼衣原体感染的阿奇霉素治疗似乎对阴道微生物群有长期影响（长达 9 个月），有利于以惰性乳球菌为主的菌群，这是沙眼衣原体感染的已知危险因素，从而增加了再次感染的可能性。
We characterized the composition and structure of the vaginal microbiota in a cohort of 149 women with genital Chlamydia trachomatis infection at baseline who were followed quarterly for 9 months after antibiotic treatment. At time of diagnosis, the vaginal microbiota was dominated by Lactobacillus iners or a diverse array of bacterial vaginosis–associated bacteria including Gardnerella vaginalis. Interestingly, L. iners–dominated communities were most common after azithromycin treatment (1 g monodose), consistent with the observed relative resistance of L. iners to azithromycin. Lactobacillus iners–dominated communities have been associated with increased risk of C. trachomatis infection, suggesting that the impact of antibiotic treatment on the vaginal microbiota could favor reinfections. These results provide support for the dual need to account for the potential perturbing effect(s) of antibiotic treatment on the vaginal microbiota, and to develop strategies to protect and restore optimal vaginal microbiota. Azithromycin treatment used for Chlamydia trachomatis infection appears to have a long-lasting impact on the vaginal microbiota (up to 9 months), favoring L. iners–dominated communities, a known risk factor for C. trachomatis infection, thus fueling an increased susceptibility to reinfection.
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影响因子：
10.5
作者：
Ma B;Forney LJ;Ravel J
通讯作者：
Ravel J
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
DOI：
10.1086/657320
发表时间：
2010-12-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Brotman RM;Klebanoff MA;Nansel TR;Yu KF;Andrews WW;Zhang J;Schwebke JR
通讯作者：
Schwebke JR
DOI：
10.1136/bmj.c1642
发表时间：
2010-04-08
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Oakeshott P;Kerry S;Aghaizu A;Atherton H;Hay S;Taylor-Robinson D;Simms I;Hay P
通讯作者：
Hay P
影响因子：
17.1
作者：
Gajer P;Brotman RM;Bai G;Sakamoto J;Schütte UM;Zhong X;Koenig SS;Fu L;Ma ZS;Zhou X;Abdo Z;Forney LJ;Ravel J
通讯作者：
Ravel J