Middle East respiratory syndrome coronavirus: transmission and phylogenetic evolution.
Middle East respiratory syndrome coronavirus: transmission and phylogenetic evolution.
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DOI:
10.1016/j.tim.2014.08.001
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发表时间:
2014-10
影响因子:
15.9
通讯作者:
Memish ZA
中科院分区:
文献类型:
--
作者:
Al-Tawfiq JA;Memish ZA
MERS-CoV continues to cause sporadic cases with amplification of cases in the healthcare setting. Camels have been linked as an intermediate host. Proper infection control measures are needed to prevent nosocomial outbreaks. The Middle East respiratory syndrome coronavirus (MERS-CoV) was first described in 2012 and, subsequently, many cases were reported with a lower case fatality rate than initial cases. Humans can become infected within their communities and transmission can then be amplified in the healthcare setting. Contact investigation among cases shows a variable amount of spread among family members and healthcare workers. So far, circulating virus strains remain similar under continuous monitoring, with no genetic changes. Here, we discuss the transmission pattern, phylogenetic evolution, and pathogenesis of MERS-CoV infection.
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