Wolbachia-Virus interactions and arbovirus control through population replacement in mosquitoes.

Wolbachia-Virus interactions and arbovirus control through population replacement in mosquitoes.
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通过蚊子中的种群替代,沃尔巴奇病毒相互作用和arbovirus控制。

DOI:
10.1080/20477724.2022.2117939
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发表时间:
2023-05
影响因子:
3.4
通讯作者:
Sinkins, Steven P.
Sinkins, Steven P.
中科院分区:
医学4区
文献类型:
--
作者:
Ant, Thomas H.;Mancini, Maria Vittoria;McNamara, Cameron J.;Rainey, Stephanie M.;Sinkins, Steven P.

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在转移到主要虫媒病毒载体埃及伊蚊中后,细胞内细菌沃尔巴克氏体的几种菌株已显示出抑制登革热、寨卡和基孔肯雅病毒的传播,这些病毒是在世界范围内引起显著发病率和死亡率的重要人类病原体。除了抑制病原体之外,许多沃尔巴克氏体菌株操纵宿主繁殖,导致细菌在昆虫种群中的入侵能力。这导致了Wolbachia作为登革热控制工具的部署,试验报告了释放地区的传播显着减少。在这里,我们讨论了抑制沃尔巴克氏体病毒的可能机制和对登革热控制长期成功的影响。我们还考虑了几份报告中提出的证据,即沃尔巴克氏体可能会导致某些病毒在特定条件下的复制增强,并得出结论,这些不应该引起任何关注的应用沃尔巴克氏体虫媒病毒控制。
Following transfer into the primary arbovirus vector Aedes aegypti, several strains of the intracellular bacterium Wolbachia have been shown to inhibit the transmission of dengue, Zika, and chikungunya viruses, important human pathogens that cause significant morbidity and mortality worldwide. In addition to pathogen inhibition, many Wolbachia strains manipulate host reproduction, resulting in an invasive capacity of the bacterium in insect populations. This has led to the deployment of Wolbachia as a dengue control tool, and trials have reported significant reductions in transmission in release areas. Here, we discuss the possible mechanisms of Wolbachia-virus inhibition and the implications for long-term success of dengue control. We also consider the evidence presented in several reports that Wolbachia may cause an enhancement of replication of certain viruses under particular conditions, and conclude that these should not cause any concerns with respect to the application of Wolbachia to arbovirus control.
DOI: 10.1098/rstb.2019.0809
发表时间: 2021-02-15
期刊: Philosophical transactions of the Royal Society of London. Series B, Biological sciences
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作者:
Ahmad NA;Mancini MV;Ant TH;Martinez J;Kamarul GMR;Nazni WA;Hoffmann AA;Sinkins SP
通讯作者: Sinkins SP
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影响因子: 6.7
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发表时间: 2019-07-03
影响因子: 2.6
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影响因子: 3.2
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