Place cells dynamically refine grid cell activities to reduce error accumulation during path integration in a continuous attractor model.
Place cells dynamically refine grid cell activities to reduce error accumulation during path integration in a continuous attractor model.
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DOI：
10.1038/s41598-022-25863-2
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发表时间：
2022-12-12
影响因子：
4.6
通讯作者：
Ji, Daoyun
中科院分区：
文献类型：
--
作者：
Fernandez-Leon, Jose A.;Uysal, Ahmet Kerim;Ji, Daoyun
导航是动物最基本的技能之一。在空间导航过程中，内侧内嗅觉皮质的网格细胞处理动物的速度和方向，以绘制环境地图。反过来，海马区细胞利用感觉信号对位置进行编码，并减少网格细胞的累积误差以进行路径整合。虽然这两种单元类型都是路径整合系统的一部分，但位置和网格单元之间的动态关系以及误差减少机制尚不清楚。在连续吸引子模型的基础上，实现了一个逼真的网格单元模型。网格单元模型被耦合到位置单元模型，以在模拟动物探索正方形竞技场的过程中处理它们的动态关系。网格单元模型处理来自位置单元的动物的速度和位置场信息。放置单元将显著的视觉特征和邻近信息与网格单元的输入结合在一起，以定义其位置字段。网格单元具有相似的空间相位，但间距和方向不同。为了确定位置单元在路径整合的误差减少中的作用，动物的位置估计被从有或没有位置场输入的网格单元活动中解码。我们发现，在勘探过程中，随着位场的出现，累积误差减小。距离动物当前位置较近的位置场比距离较远的位置场对误差减少的贡献更大。空间编码单元的场可以作为空间锚定信号，用于网格单元的精确路径整合。
Navigation is one of the most fundamental skills of animals. During spatial navigation, grid cells in the medial entorhinal cortex process speed and direction of the animal to map the environment. Hippocampal place cells, in turn, encode place using sensory signals and reduce the accumulated error of grid cells for path integration. Although both cell types are part of the path integration system, the dynamic relationship between place and grid cells and the error reduction mechanism is yet to be understood. We implemented a realistic model of grid cells based on a continuous attractor model. The grid cell model was coupled to a place cell model to address their dynamic relationship during a simulated animal’s exploration of a square arena. The grid cell model processed the animal’s velocity and place field information from place cells. Place cells incorporated salient visual features and proximity information with input from grid cells to define their place fields. Grid cells had similar spatial phases but a diversity of spacings and orientations. To determine the role of place cells in error reduction for path integration, the animal’s position estimates were decoded from grid cell activities with and without the place field input. We found that the accumulated error was reduced as place fields emerged during the exploration. Place fields closer to the animal’s current location contributed more to the error reduction than remote place fields. Place cells’ fields encoding space could function as spatial anchoring signals for precise path integration by grid cells.
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影响因子：
5.3
作者：
DEADWYLER, SA;WEST, JR;LYNCH, G
通讯作者：
LYNCH, G
影响因子：
56.9
作者：
Fyhn, M;Molden, S;Moser, MB
通讯作者：
Moser, MB
影响因子：
25
作者：
Gil, Mariana;Ancau, Mihai;Monyer, Hannah
通讯作者：
Monyer, Hannah
影响因子：
25
作者：
Bonnevie, Tora;Dunn, Benjamin;Moser, May-Britt
通讯作者：
Moser, May-Britt
DOI：
10.1523/jneurosci.6048-08.2009
发表时间：
2009-06-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
de Almeida L;Idiart M;Lisman JE
通讯作者：
Lisman JE