Recent Advancements in Metallic Drug-Eluting Implants.
Recent Advancements in Metallic Drug-Eluting Implants.
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DOI：
10.3390/pharmaceutics15010223
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发表时间：
2023-01-09
期刊：
影响因子：
5.4
通讯作者：
Bathaei MS
中科院分区：
文献类型：
--
作者：
Alshimaysawee S;Fadhel Obaid R;Al-Gazally ME;Alexis Ramírez-Coronel A;Bathaei MS
在过去的十年中，金属药物洗脱种植体在骨科和牙科领域的应用具有重要意义，可以控制药物释放，特别是预防种植体相关的感染。最近的研究表明，负载药物的金属植入物取代了传统的裸金属植入物，以实现持续和可控的药物释放，从而达到理想的局部治疗浓度。掺入的活性分子还具有促进骨传导和血管生成、抑制细菌入侵和调节宿主反应等次要功能。本文综述了近三年来不同给药系统金属药物洗脱植入体的发展趋势。为了达到这一目的，已经开发了各种类型的药物洗脱植入物，这取决于所装载的药物或制剂。这些药物包括抗炎药、抗生素、生长因子和抗吸收药物。
Over the past decade, metallic drug-eluting implants have gained significance in orthopedic and dental applications for controlled drug release, specifically for preventing infection associated with implants. Recent studies showed that metallic implants loaded with drugs were substituted for conventional bare metal implants to achieve sustained and controlled drug release, resulting in a desired local therapeutic concentration. A number of secondary features can be provided by the incorporated active molecules, including the promotion of osteoconduction and angiogenesis, the inhibition of bacterial invasion, and the modulation of host body reaction. This paper reviews recent trends in the development of the metallic drug-eluting implants with various drug delivery systems in the past three years. There are various types of drug-eluting implants that have been developed to meet this purpose, depending on the drug or agents that have been loaded on them. These include anti-inflammatory drugs, antibiotics agents, growth factors, and anti-resorptive drugs.
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影响因子：
4.6
作者：
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通讯作者：
Mozafari, Masoud
影响因子：
4.1
作者：
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DOI：
10.1016/j.msec.2020.111062
发表时间：
2020-10-01
影响因子：
7.9
作者：
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通讯作者：
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影响因子：
4.2
作者：
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通讯作者：
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