Study of Microbiomes in Aseptically Collected Samples of Human Breast Tissue Using Needle Biopsy and the Potential Role of in situ Tissue Microbiomes for Promoting Malignancy.
Study of Microbiomes in Aseptically Collected Samples of Human Breast Tissue Using Needle Biopsy and the Potential Role of in situ Tissue Microbiomes for Promoting Malignancy.
复制标题
使用针吸活检无菌采集的人类乳腺组织样本中的微生物组研究以及原位组织微生物组促进恶性肿瘤的潜在作用
DOI：
10.3389/fonc.2018.00318
复制
发表时间：
2018
影响因子：
4.7
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Meng S;Chen B;Yang J;Wang J;Zhu D;Meng Q;Zhang L
Mounting evidence suggests that changes in microbiome are linked to development of cancer and its aggressiveness. Microbiome profiles in human breast tissue previously presumed to be sterile, have recently been characterized using high-throughput technologies. Recent findings of microbiome variation between benign and malignant disease provides a rationale for exploring microbiomes associated with cancer during tumor progression. We assessed microbiomes of aseptically collected human breast tissue samples in this study, using needle biopsy from patients with benign and malignant tumors of different histological grading, using 16S rRNA gene amplicon sequencing. This is consistent with previous studies, and our results identified distinct microbiome profiles in breast tissues from women with cancer as compared to women with benign breast disease in Chinese cohorts. The enriched microbial biomarkers in malignant tissue included genus Propionicimonas and families Micrococcaceae, Caulobacteraceae, Rhodobacteraceae, Nocardioidaceae, Methylobacteriaceae, which appeared to be ethno-specific. Further, we compared microbiome profiles in malignant tissues of three different histological grades. The relative abundance of family Bacteroidaceae decreased and that of genus Agrococcus increased with the development of malignancy. KEGG pathways inferred by PICRUSt showed that biotin and glycerophospholipid metabolism had significant differences in all three grades. Glycerophospholipid and ribosome biogenesis increased in grade III tissue as compared to grades I and II. Flavonoid biosynthesis significantly decreased in grade III tissue. The specific correlation of these potential microbial biomarkers and indicated pathways with advanced disease could have broad implications in the diagnosis and staging of breast cancer. Further large-cohort investigation of the breast cancer microbiome and its potential mechanism in breast cancer development are essential.
登录
查看更多内容
影响因子：
3.7
作者：
Mason MR;Nagaraja HN;Camerlengo T;Joshi V;Kumar PS
通讯作者：
Kumar PS
影响因子：
4.6
作者：
Chan AA;Bashir M;Rivas MN;Duvall K;Sieling PA;Pieber TR;Vaishampayan PA;Love SM;Lee DJ
通讯作者：
Lee DJ
类黄酮、类黄酮亚类和乳腺癌风险：流行病学研究的荟萃分析。
影响因子：
3.7
作者：
Hui C;Qi X;Qianyong Z;Xiaoli P;Jundong Z;Mantian M
通讯作者：
Mantian M
微生物组和癌症。
DOI：
10.1038/nrc3610
发表时间：
2013-11
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
--
影响因子：
5.8
作者：
Parks, Donovan H.;Beiko, Robert G.
通讯作者：
Beiko, Robert G.